The role of HIF-1 and ROS in cellular and systemic responses to chronic intermittent hypoxia

Nanduri R. Prabhakar, Gregg L Semenza

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sleep-disordered breathing with recurrent apnea is a major cause of morbidity and mortality. Affected individuals have increased risk of systemic hypertension. Sleep apnea results in chronic intermittent hypoxia (CIH). Exposure of rodents to CIH is sufficient to induce hypertension by activating the carotid body reflexes resulting in sympathetic excitation, elevated circulating catecholamines, blood pressure, and ventilation. CIH induces increased levels of reactive oxygen species (ROS) and antioxidant treatment blocks CIH-induced hypertension. The transcriptional activator hypoxia-inducible factor 1 (HIF-1) is induced when mice or cultured cells are subjected to CIH, an effect that is blocked by antioxidants. The carotid bodies from mice heterozygous for a null allele at the locus encoding the HIF-1α subunit appear histologically normal but do not respond to continuous hypoxia or CIH. In contrast to wild-type littermates, when heterozygous-null mice are subjected to CIH they do not develop hypertension or increased levels of HIF-1, catecholamines, or ROS.

Original languageEnglish (US)
Title of host publicationIntermittent Hypoxia: From Molecular Mechanisms To Clinical Applications
PublisherNova Science Publishers, Inc.
Pages355-369
Number of pages15
ISBN (Print)9781622577101
StatePublished - Jan 2013

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Hypoxia-Inducible Factor 1
Reactive Oxygen Species
Hypertension
Carotid Body
Sleep Apnea Syndromes
Catecholamines
Antioxidants
Hypoxia
Apnea
Ventilation
Reflex
Cultured Cells
Rodentia
Alleles
Blood Pressure
Morbidity
Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prabhakar, N. R., & Semenza, G. L. (2013). The role of HIF-1 and ROS in cellular and systemic responses to chronic intermittent hypoxia. In Intermittent Hypoxia: From Molecular Mechanisms To Clinical Applications (pp. 355-369). Nova Science Publishers, Inc..

The role of HIF-1 and ROS in cellular and systemic responses to chronic intermittent hypoxia. / Prabhakar, Nanduri R.; Semenza, Gregg L.

Intermittent Hypoxia: From Molecular Mechanisms To Clinical Applications. Nova Science Publishers, Inc., 2013. p. 355-369.

Research output: Chapter in Book/Report/Conference proceedingChapter

Prabhakar, NR & Semenza, GL 2013, The role of HIF-1 and ROS in cellular and systemic responses to chronic intermittent hypoxia. in Intermittent Hypoxia: From Molecular Mechanisms To Clinical Applications. Nova Science Publishers, Inc., pp. 355-369.
Prabhakar NR, Semenza GL. The role of HIF-1 and ROS in cellular and systemic responses to chronic intermittent hypoxia. In Intermittent Hypoxia: From Molecular Mechanisms To Clinical Applications. Nova Science Publishers, Inc. 2013. p. 355-369
Prabhakar, Nanduri R. ; Semenza, Gregg L. / The role of HIF-1 and ROS in cellular and systemic responses to chronic intermittent hypoxia. Intermittent Hypoxia: From Molecular Mechanisms To Clinical Applications. Nova Science Publishers, Inc., 2013. pp. 355-369
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