The role of HGF/c-MET in head and neck squamous cell carcinoma

Tanguy Y. Seiwert, Tim N. Beck, Ravi Salgia

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Head and Neck Squamous Cell Carcinoma (HNSCC) remains a formidable challenge to physicians, scientists, and patients. New targets that can be exploited to improve the outcome of patients afflicted with this dreadful disease are desperately needed: one such potential target is c-MET. The c-MET receptor tyrosine kinase, also known as hepatocyte growth factor receptor (HGFR), is robustly overexpressed and sometimes mutated or amplified in head and neck cancer cells, while overexpression of its ligand, hepatocyte growth factor/scatter factor (HGF/SF), often occurs in tumor-adjacent mesenchymal cells, providing paracrine signals that support tumor growth. Activation of c-MET stimulates numerous downstream signaling pathways that contribute to tumor growth, including GRB2/RAS, PI3K, STAT3, SRC, β-catenin, and Notch. Overexpression or anomalous activation of c-MET is often associated with resistance to targeted therapies inhibiting receptor tyrosine kinases (RTKs), such as the epidermal growth factor receptor (EGFR), that communicate to similar growth factor cascades. In this review, we emphasize the role of c-MET/HGF in HNSCC as well as the potential for therapeutic targeting of this receptor.

Original languageEnglish (US)
Title of host publicationMolecular Determinants of Head and Neck Cancer
PublisherSpringer New York
Pages91-111
Number of pages21
ISBN (Electronic)9781461488156
ISBN (Print)9781461488149
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • EGFR
  • HER
  • HGF
  • HGFR
  • Head and neck cancer
  • Receptor tyrosine kinases
  • Squamous cell cancer
  • Targeted therapy
  • c-MET

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Seiwert, T. Y., Beck, T. N., & Salgia, R. (2014). The role of HGF/c-MET in head and neck squamous cell carcinoma. In Molecular Determinants of Head and Neck Cancer (pp. 91-111). Springer New York. https://doi.org/10.1007/978-1-4614-8815-6_5