The role of hematopoietic growth factors and oncogenes in leukemogenesis

Michael B. Kastan, Lewis C. Strauss, Curt I. Civin

Research output: Contribution to journalArticlepeer-review

Abstract

Understanding of the roles and molecular mechanisms of hematopoietic growth factors has increased greatly in recent years. This past decade has also brought us tantalizingly close to linking a group of genes normally involved in the regulation of growth and differentiation-the cellular proto oncogenes-to the process of malignant transformation. In this article, we review the known actions of hematopoietic growth factors in normal hematopoiesis and in hematologic malignancies. We then discuss current concepts of the roles of proto-oncogenes in normal cells and their potential involvement in leukemogenic events. A merging of these concepts with classical hypotheses of multistage carcinogenesis is emphasized.

Original languageEnglish (US)
Pages (from-to)249-267
Number of pages19
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume11
Issue number3
StatePublished - 1989

Keywords

  • Hematologic malignancies
  • Hematopoietic growth factors
  • Malignant transformation
  • Proto-oncogenes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

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