The role of genetics in host responses to mucosal and invasive candidiasis

Shmuel Shoham, Simon F. Dufresne

Research output: Contribution to journalArticle

Abstract

The development of mucosal and invasive candidiasis depends upon a variety of innate and acquired risk factors. The number of genes known to be important for immunity against candidiasis has been increasing. Studies of variants of these genes are facilitating our knowledge of host predisposition to infection. Insights gleaned from genetic variants identified in patients with primary immunodeficiency syndromes such as chronic mucocutaneous candidiasis have further aided in this process. This article reviews data from genomic association studies in patients with such syndromes and in broader patient populations. These studies are placed within the framework of our current understanding of antifungal host defenses.

Original languageEnglish (US)
Pages (from-to)262-268
Number of pages7
JournalCurrent Fungal Infection Reports
Volume5
Issue number4
DOIs
StatePublished - Jan 1 2011

Keywords

  • Candida
  • Candidiasis
  • Dectin-1
  • Genes
  • Genetics
  • Genomic association studies
  • Genomics
  • Host defenses
  • Host responses
  • Immunity
  • Immunodeficiency
  • Invasive candidiasis
  • Mucosal candidiasis
  • RVVC
  • Recurrent vulvovaginal candidiasis
  • Review
  • Toll-like receptors

ASJC Scopus subject areas

  • Infectious Diseases

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