TY - JOUR
T1 - The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes
T2 - Convergent findings in a mouse model of neglect
AU - Montalvo-Ortiz, Janitza L.
AU - Bordner, Kelly A.
AU - Carlyle, Becky C.
AU - Gelernter, Joel
AU - Simen, Arthur A.
AU - Kaufman, Joan
N1 - Funding Information:
This work was supported by the NIH R01MH098073 (JK); the National Center for Posttraumatic Stress Disorder-Veterans Affairs Connecticut (JG, JK); the VA Cooperative Study #575B, Genomics of Posttraumatic Stress Disorder in Veterans (JG, JK) and the Biological Sciences Training Program through Grant Number 5T32 MH14276 (JLMO).
Publisher Copyright:
© 2016
PY - 2016/12/15
Y1 - 2016/12/15
N2 - Early life neglect increases risk for the development of psychopathologies during childhood and adulthood, including depression and anxiety disorders. We recently reported epigenetic changes in DNA derived from saliva in three genes predicted depression in a cohort of maltreated children: DNA-binding protein inhibitor ID-3 (ID3), Glutamate NMDA Receptor (GRIN1), and Tubulin Polymerization Promoting Protein (TPPP). To validate the role of these genes in depression risk, secondary analyses were conducted of gene expression data obtained from medial prefrontal cortex (mPFC) tissue of mice subjected to a model of maternal neglect which included maternal separation and early weaning (MSEW). Anxiety and depression-like phenotype data derived using the elevated plus maze (EPM) and forced swimming test (FST), respectively, were also available for secondary analyses. Behavioral tests were conducted in MSEW and control adult male mice when they were between 65 and 80 days old. ID3, GRIN1 and TPPP gene expression in the mPFC were found to significantly predict behavioral differences in the EPM and FST. These results further support the role of these genes in the etiology of depressive and anxiety phenotypes following early life stress.
AB - Early life neglect increases risk for the development of psychopathologies during childhood and adulthood, including depression and anxiety disorders. We recently reported epigenetic changes in DNA derived from saliva in three genes predicted depression in a cohort of maltreated children: DNA-binding protein inhibitor ID-3 (ID3), Glutamate NMDA Receptor (GRIN1), and Tubulin Polymerization Promoting Protein (TPPP). To validate the role of these genes in depression risk, secondary analyses were conducted of gene expression data obtained from medial prefrontal cortex (mPFC) tissue of mice subjected to a model of maternal neglect which included maternal separation and early weaning (MSEW). Anxiety and depression-like phenotype data derived using the elevated plus maze (EPM) and forced swimming test (FST), respectively, were also available for secondary analyses. Behavioral tests were conducted in MSEW and control adult male mice when they were between 65 and 80 days old. ID3, GRIN1 and TPPP gene expression in the mPFC were found to significantly predict behavioral differences in the EPM and FST. These results further support the role of these genes in the etiology of depressive and anxiety phenotypes following early life stress.
KW - DNA-binding protein inhibitor ID-3 (ID3)
KW - Depression
KW - Glutamate NMDA receptor (GRIN1)
KW - Methylation
KW - Neglect
KW - Tubulin polymerization promoting protein (TPPP)
UR - http://www.scopus.com/inward/record.url?scp=84982094777&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982094777&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2016.08.010
DO - 10.1016/j.bbr.2016.08.010
M3 - Article
C2 - 27506655
AN - SCOPUS:84982094777
SN - 0166-4328
VL - 315
SP - 71
EP - 74
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -