The role of GATA3 in breast carcinomas: A review

Rebecca Asch-Kendrick, Ashley Cimino-Mathews

Research output: Contribution to journalReview articlepeer-review

Abstract

Summary GATA3 is a zinc-binding transcription factor that regulates the differentiation of many human tissue types, including the mammary gland. In surgical pathology, immunohistochemistry for GATA3 is largely used to support urothelial or breast origin in a carcinoma of unknown origin. GATA3 is sensitive but not entirely specific in this setting. Although GATA3 labeling is highest in estrogen receptor-positive carcinomas, it also labels estrogen receptor-negative carcinomas and thus has particular diagnostic utility in the setting of triple-negative breast carcinomas, which are typically negative for other mammary-specific markers.

Original languageEnglish (US)
Pages (from-to)37-47
Number of pages11
JournalHuman pathology
Volume48
DOIs
StatePublished - Feb 1 2016

Keywords

  • Breast cancer
  • Differential diagnoses
  • GATA3
  • Immunohistochemistry
  • Surgical pathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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