The role of free prostate-specific antigen in prostate cancer detection.

M. Han, S. R. Potter, A. W. Partin

Research output: Contribution to journalReview articlepeer-review


Prostate-specific antigen (PSA) is the most important serum tumor marker for prostate cancer detection. Free PSA is one of the many molecular forms of PSA that have been identified. Percent free PSA improves the specificity (elimination of unnecessary biopsies) for prostate cancer detection in men with nonsuspicious digital prostate examination and total serum PSA ranges between 4 and 10 ng/mL. Further study is necessary to determine the optimal clinical utility of percent free PSA in men with a total serum PSA level of less than 4 ng/mL. In addition, the level of free PSA may be affected by many factors, including age, prostate volume, prostate manipulation, sample handling, and type of assay used.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalCurrent urology reports
Issue number1
StatePublished - May 2000

ASJC Scopus subject areas

  • Urology


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