The role of estrogen in mood disorders in women

Research output: Contribution to journalReview articlepeer-review


Major depression is twice as common in women as men and depressive episodes appear to be more common in women with bipolar disorder. There is accumulating evidence that, in at least some women, reproductive-related hormonal changes may play a role in increasing the risk of depressive symptoms premenstrually, postpartum and in the perimenopausal period. In this review, the evidence for the role of hormonal fluctuations, specifically estrogen, in triggering depressive symptoms in a subgroup of women is summarized. In addition, the potential role of estrogen in triggering depressive symptoms via its effects on the serotonergic system, brain-derived neurotrophic factor and Protein Kinase C is reviewed.

Original languageEnglish (US)
Pages (from-to)280-290
Number of pages11
JournalInternational Review of Psychiatry
Issue number3
StatePublished - Aug 2003
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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