The role of epigenetics in respiratory health in urban populations in low and middle-income countries

Nicole M. Robertson, Alex Kayongo, Trishul Siddharthan, Suzanne L. Pollard, Jose Gomez Villalobos, Christine Ladd-Acosta, Bruce Kirenga, William Checkley

Research output: Contribution to journalReview article

Abstract

As urbanization increases in low- and middle-income countries (LMICs), urban populations will be increasingly exposed to a range of environmental risk factors for non-communicable diseases. Inadequate living conditions in urban settings may influence mechanisms that regulate gene expression, leading to the development of non-communicable respiratory diseases. We conducted a systematic review of the literature to assess the relationship between respiratory health and epigenetic factors to urban environmental exposures observed in LMICs using MEDLINE, PubMed, EMBASE, and Google Scholar searching a combination of the terms: epigenetics, chronic respiratory diseases (CRDs), lung development, chronic obstructive airway disease, and asthma. A total of 2835 articles were obtained, and 48 articles were included in this review. We found that environmental factors during early development are related to epigenetic effects that may be associated with a higher risk of CRDs. Epigenetic dysregulation of gene expression of the histone deacetylase (HDAC) and histone acetyltransferase gene families was likely involved in lung health of slum dwellers. Respiratory-related environmental exposures influence HDAC function and deoxyribonucleic acid methylation and are important risk factors in the development of CRD. Additional epigenetic research is needed to improve our understanding of associations between environmental exposures and non-communicable respiratory diseases.

Original languageEnglish (US)
JournalGlobal Health, Epidemiology and Genomics
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Urban Population
Epigenomics
Environmental Exposure
Health
Chronic Disease
Histone Deacetylases
Poverty Areas
Histone Acetyltransferases
Gene Expression
Lung
Urbanization
Social Conditions
PubMed
MEDLINE
Chronic Obstructive Pulmonary Disease
Methylation
Asthma
DNA
Research
Genes

Keywords

  • Chronic respiratory diseases
  • epigenetics
  • low and middle-income countries
  • slum dwellers

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

The role of epigenetics in respiratory health in urban populations in low and middle-income countries. / Robertson, Nicole M.; Kayongo, Alex; Siddharthan, Trishul; Pollard, Suzanne L.; Villalobos, Jose Gomez; Ladd-Acosta, Christine; Kirenga, Bruce; Checkley, William.

In: Global Health, Epidemiology and Genomics, 01.01.2019.

Research output: Contribution to journalReview article

Robertson, Nicole M. ; Kayongo, Alex ; Siddharthan, Trishul ; Pollard, Suzanne L. ; Villalobos, Jose Gomez ; Ladd-Acosta, Christine ; Kirenga, Bruce ; Checkley, William. / The role of epigenetics in respiratory health in urban populations in low and middle-income countries. In: Global Health, Epidemiology and Genomics. 2019.
@article{3d98f28fe0994a048890a0b32efaa962,
title = "The role of epigenetics in respiratory health in urban populations in low and middle-income countries",
abstract = "As urbanization increases in low- and middle-income countries (LMICs), urban populations will be increasingly exposed to a range of environmental risk factors for non-communicable diseases. Inadequate living conditions in urban settings may influence mechanisms that regulate gene expression, leading to the development of non-communicable respiratory diseases. We conducted a systematic review of the literature to assess the relationship between respiratory health and epigenetic factors to urban environmental exposures observed in LMICs using MEDLINE, PubMed, EMBASE, and Google Scholar searching a combination of the terms: epigenetics, chronic respiratory diseases (CRDs), lung development, chronic obstructive airway disease, and asthma. A total of 2835 articles were obtained, and 48 articles were included in this review. We found that environmental factors during early development are related to epigenetic effects that may be associated with a higher risk of CRDs. Epigenetic dysregulation of gene expression of the histone deacetylase (HDAC) and histone acetyltransferase gene families was likely involved in lung health of slum dwellers. Respiratory-related environmental exposures influence HDAC function and deoxyribonucleic acid methylation and are important risk factors in the development of CRD. Additional epigenetic research is needed to improve our understanding of associations between environmental exposures and non-communicable respiratory diseases.",
keywords = "Chronic respiratory diseases, epigenetics, low and middle-income countries, slum dwellers",
author = "Robertson, {Nicole M.} and Alex Kayongo and Trishul Siddharthan and Pollard, {Suzanne L.} and Villalobos, {Jose Gomez} and Christine Ladd-Acosta and Bruce Kirenga and William Checkley",
year = "2019",
month = "1",
day = "1",
doi = "10.1017/gheg.2019.7",
language = "English (US)",
journal = "Global Health, Epidemiology and Genomics",
issn = "2054-4200",
publisher = "Cambridge University Press",

}

TY - JOUR

T1 - The role of epigenetics in respiratory health in urban populations in low and middle-income countries

AU - Robertson, Nicole M.

AU - Kayongo, Alex

AU - Siddharthan, Trishul

AU - Pollard, Suzanne L.

AU - Villalobos, Jose Gomez

AU - Ladd-Acosta, Christine

AU - Kirenga, Bruce

AU - Checkley, William

PY - 2019/1/1

Y1 - 2019/1/1

N2 - As urbanization increases in low- and middle-income countries (LMICs), urban populations will be increasingly exposed to a range of environmental risk factors for non-communicable diseases. Inadequate living conditions in urban settings may influence mechanisms that regulate gene expression, leading to the development of non-communicable respiratory diseases. We conducted a systematic review of the literature to assess the relationship between respiratory health and epigenetic factors to urban environmental exposures observed in LMICs using MEDLINE, PubMed, EMBASE, and Google Scholar searching a combination of the terms: epigenetics, chronic respiratory diseases (CRDs), lung development, chronic obstructive airway disease, and asthma. A total of 2835 articles were obtained, and 48 articles were included in this review. We found that environmental factors during early development are related to epigenetic effects that may be associated with a higher risk of CRDs. Epigenetic dysregulation of gene expression of the histone deacetylase (HDAC) and histone acetyltransferase gene families was likely involved in lung health of slum dwellers. Respiratory-related environmental exposures influence HDAC function and deoxyribonucleic acid methylation and are important risk factors in the development of CRD. Additional epigenetic research is needed to improve our understanding of associations between environmental exposures and non-communicable respiratory diseases.

AB - As urbanization increases in low- and middle-income countries (LMICs), urban populations will be increasingly exposed to a range of environmental risk factors for non-communicable diseases. Inadequate living conditions in urban settings may influence mechanisms that regulate gene expression, leading to the development of non-communicable respiratory diseases. We conducted a systematic review of the literature to assess the relationship between respiratory health and epigenetic factors to urban environmental exposures observed in LMICs using MEDLINE, PubMed, EMBASE, and Google Scholar searching a combination of the terms: epigenetics, chronic respiratory diseases (CRDs), lung development, chronic obstructive airway disease, and asthma. A total of 2835 articles were obtained, and 48 articles were included in this review. We found that environmental factors during early development are related to epigenetic effects that may be associated with a higher risk of CRDs. Epigenetic dysregulation of gene expression of the histone deacetylase (HDAC) and histone acetyltransferase gene families was likely involved in lung health of slum dwellers. Respiratory-related environmental exposures influence HDAC function and deoxyribonucleic acid methylation and are important risk factors in the development of CRD. Additional epigenetic research is needed to improve our understanding of associations between environmental exposures and non-communicable respiratory diseases.

KW - Chronic respiratory diseases

KW - epigenetics

KW - low and middle-income countries

KW - slum dwellers

UR - http://www.scopus.com/inward/record.url?scp=85076177860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076177860&partnerID=8YFLogxK

U2 - 10.1017/gheg.2019.7

DO - 10.1017/gheg.2019.7

M3 - Review article

AN - SCOPUS:85076177860

JO - Global Health, Epidemiology and Genomics

JF - Global Health, Epidemiology and Genomics

SN - 2054-4200

ER -