The role of epidemiology in the introduction of Vi polysaccharide typhoid fever vaccines in Asia

Camilo J. Acosta, Claudia M. Galindo, R. Leon Ochiai, M. Carolina Danovaro-Holliday, Anne Laure Page, Vu Dinh Thiem, Jin Kyoung Park, Eunsik Park, Hyewon Koo, Xuan Yi Wang, Remon Abu-Elyazeed, Mohammad Ali, M. John Albert, Bernard Ivanoff, Tikki Pang, Zhi Yi Xu, John D. Clemens

Research output: Contribution to journalArticlepeer-review


Despite the availability of at least two licensed typhoid fever vaccines - injectable sub-unit Vi polysaccharide vaccine and live, oral Ty21a vaccine - for the last decade, these vaccines have not been widely introduced in public-health programmes in countries endemic for typhoid fever. The goal of the multidisciplinary DOMI (Diseases of the Most Impoverished) typhoid fever programme is to generate policy-relevant data to support public decision-making regarding the introduction of Vi polysaccharide typhoid fever immunization programmes in China, Viet Nam, Pakistan, India, Bangladesh, and Indonesia. Through epidemiological studies, the DOMI Programme is generating these data and is offering a model for the accelerated, rational introduction of new vaccines into health programmes in low-income countries. Practical and specific examples of the role of epidemiology are described in this paper. These examples cover: (a) selection of available typhoid fever vaccines to be introduced in the programme, (b) generation of policy-relevant data, (c) providing the 'backbone' for the implementation of other multidisciplinary projects, and (d) generation of unexpected but useful information relevant for the introduction of vaccines. Epidemiological studies contribute to all stages of development of vaccine evaluation and introduction.

Original languageEnglish (US)
Pages (from-to)240-245
Number of pages6
JournalJournal of Health, Population and Nutrition
Issue number3
StatePublished - Sep 2004
Externally publishedYes


  • Asia
  • Epidemiology
  • Salmonella
  • Typhi
  • Typhoid fever
  • Vaccine
  • Vaccinology

ASJC Scopus subject areas

  • Food Science
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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