The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates

Jeremy D. Coplan; Chadi G. Abdallah; Cheuk Y. Tang; Sanjay J. Mathew; Jose Martinez; Patrick R. Hof; Eric L.P. Smith; Andrew J. Dwork; Tarique D. Perera; Gustavo Pantol; David Carpenter; Leonard A. Rosenblum; Dikoma C. Shungu; Joel Gelernter; Arie Kaffman; Andrea Jackowski; Joan Kaufman; Jack M. Gorman

doi:10.1016/j.neulet.2010.06.012

The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates

Jeremy D. Coplan, Chadi G. Abdallah, Cheuk Y. Tang, Sanjay J. Mathew, Jose Martinez, Patrick R. Hof, Eric L.P. Smith, Andrew J. Dwork, Tarique D. Perera, Gustavo Pantol, David Carpenter, Leonard A. Rosenblum, Dikoma C. Shungu, Joel Gelernter, Arie Kaffman, Andrea Jackowski, Joan Kaufman, Jack M. Gorman

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) may be effective in treating depression. Parental verbal abuse has been linked to decreased fractional anisotropy (FA) of white matter and reduced FA correlated with depression and anxiety scores. Utilizing a nonhuman primate model of mood and anxiety disorders following disrupted mother-infant attachment, we examined whether adverse rearing conditions lead to white matter impairment of the ALIC. We examined white matter integrity using Diffusion Tensor Imaging (DTI) on a 3T-MRI. Twenty-one adult male Bonnet macaques participated in this study: 12 were reared under adverse [variable foraging demand (VFD)] conditions whereas 9 were reared under normative conditions. We examined ALIC, posterior limb of the internal capsule (PLIC) and occipital white matter. VFD rearing was associated with significant reductions in FA in the ALIC with no changes evident in the PLIC or occipital cortex white matter. Adverse rearing in monkeys persistently impaired frontal white matter tract integrity, a novel substrate for understanding affective susceptibility.

Original language	English (US)
Pages (from-to)	93-96
Number of pages	4
Journal	Neuroscience Letters
Volume	480
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2010.06.012
State	Published - Aug 2010
Externally published	Yes

Keywords

Diffusion tensor imaging
Fractional anisotropy
Variable foraging demand
White matter integrity

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2010.06.012

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Coplan, J. D., Abdallah, C. G., Tang, C. Y., Mathew, S. J., Martinez, J., Hof, P. R., Smith, E. L. P., Dwork, A. J., Perera, T. D., Pantol, G., Carpenter, D., Rosenblum, L. A., Shungu, D. C., Gelernter, J., Kaffman, A., Jackowski, A., Kaufman, J., & Gorman, J. M. (2010). The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates. Neuroscience Letters, 480(2), 93-96. https://doi.org/10.1016/j.neulet.2010.06.012

Coplan, JD, Abdallah, CG, Tang, CY, Mathew, SJ, Martinez, J, Hof, PR, Smith, ELP, Dwork, AJ, Perera, TD, Pantol, G, Carpenter, D, Rosenblum, LA, Shungu, DC, Gelernter, J, Kaffman, A, Jackowski, A, Kaufman, J & Gorman, JM 2010, 'The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates', Neuroscience Letters, vol. 480, no. 2, pp. 93-96. https://doi.org/10.1016/j.neulet.2010.06.012

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title = "The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates",

abstract = "Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) may be effective in treating depression. Parental verbal abuse has been linked to decreased fractional anisotropy (FA) of white matter and reduced FA correlated with depression and anxiety scores. Utilizing a nonhuman primate model of mood and anxiety disorders following disrupted mother-infant attachment, we examined whether adverse rearing conditions lead to white matter impairment of the ALIC. We examined white matter integrity using Diffusion Tensor Imaging (DTI) on a 3T-MRI. Twenty-one adult male Bonnet macaques participated in this study: 12 were reared under adverse [variable foraging demand (VFD)] conditions whereas 9 were reared under normative conditions. We examined ALIC, posterior limb of the internal capsule (PLIC) and occipital white matter. VFD rearing was associated with significant reductions in FA in the ALIC with no changes evident in the PLIC or occipital cortex white matter. Adverse rearing in monkeys persistently impaired frontal white matter tract integrity, a novel substrate for understanding affective susceptibility.",

keywords = "Diffusion tensor imaging, Fractional anisotropy, Variable foraging demand, White matter integrity",

author = "Coplan, {Jeremy D.} and Abdallah, {Chadi G.} and Tang, {Cheuk Y.} and Mathew, {Sanjay J.} and Jose Martinez and Hof, {Patrick R.} and Smith, {Eric L.P.} and Dwork, {Andrew J.} and Perera, {Tarique D.} and Gustavo Pantol and David Carpenter and Rosenblum, {Leonard A.} and Shungu, {Dikoma C.} and Joel Gelernter and Arie Kaffman and Andrea Jackowski and Joan Kaufman and Gorman, {Jack M.}",

note = "Funding Information: Many thanks to Dr Bruce Sharf, Douglas Rosenblum, Shirne Baptiste, and Ann Marie Lacobelle for invaluable technical experience. Dr Coplan receives grant support from GlaxoSmithKline and Pfizer pharmaceuticals. Supported in part by funding from NIMH grant R21MH066748 (JDC), NIDA grant K24 DA15105 (JG), and the VA CT Research Enhancement Award Program (JG). Dr Coplan is on the Pfizer advisory board and gives talks for BMS, AstraZeneca, GlaxoSmithKline, Pfizer. Dr. Gorman is an employee of Comprehensive NeuroScience, Inc., a corporation that receives funding from the pharmaceutical industry for some of its projects. No biomedical financial interests or potential conflicts of interest are reported for Drs Abdallah, Tang, Martinez, Smith, Dwork, Perera, Pantol, Carpenter, Rosenblum, Gelernter, Hof, Mathew, Shungu, Kaffman, Kaufman, or Jackowski.",

year = "2010",

month = aug,

doi = "10.1016/j.neulet.2010.06.012",

language = "English (US)",

volume = "480",

pages = "93--96",

journal = "Neuroscience Letters",

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T1 - The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates

AU - Coplan, Jeremy D.

AU - Abdallah, Chadi G.

AU - Tang, Cheuk Y.

AU - Mathew, Sanjay J.

AU - Martinez, Jose

AU - Hof, Patrick R.

AU - Smith, Eric L.P.

AU - Dwork, Andrew J.

AU - Perera, Tarique D.

AU - Pantol, Gustavo

AU - Carpenter, David

AU - Rosenblum, Leonard A.

AU - Shungu, Dikoma C.

AU - Gelernter, Joel

AU - Kaffman, Arie

AU - Jackowski, Andrea

AU - Kaufman, Joan

AU - Gorman, Jack M.

N1 - Funding Information: Many thanks to Dr Bruce Sharf, Douglas Rosenblum, Shirne Baptiste, and Ann Marie Lacobelle for invaluable technical experience. Dr Coplan receives grant support from GlaxoSmithKline and Pfizer pharmaceuticals. Supported in part by funding from NIMH grant R21MH066748 (JDC), NIDA grant K24 DA15105 (JG), and the VA CT Research Enhancement Award Program (JG). Dr Coplan is on the Pfizer advisory board and gives talks for BMS, AstraZeneca, GlaxoSmithKline, Pfizer. Dr. Gorman is an employee of Comprehensive NeuroScience, Inc., a corporation that receives funding from the pharmaceutical industry for some of its projects. No biomedical financial interests or potential conflicts of interest are reported for Drs Abdallah, Tang, Martinez, Smith, Dwork, Perera, Pantol, Carpenter, Rosenblum, Gelernter, Hof, Mathew, Shungu, Kaffman, Kaufman, or Jackowski.

PY - 2010/8

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N2 - Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) may be effective in treating depression. Parental verbal abuse has been linked to decreased fractional anisotropy (FA) of white matter and reduced FA correlated with depression and anxiety scores. Utilizing a nonhuman primate model of mood and anxiety disorders following disrupted mother-infant attachment, we examined whether adverse rearing conditions lead to white matter impairment of the ALIC. We examined white matter integrity using Diffusion Tensor Imaging (DTI) on a 3T-MRI. Twenty-one adult male Bonnet macaques participated in this study: 12 were reared under adverse [variable foraging demand (VFD)] conditions whereas 9 were reared under normative conditions. We examined ALIC, posterior limb of the internal capsule (PLIC) and occipital white matter. VFD rearing was associated with significant reductions in FA in the ALIC with no changes evident in the PLIC or occipital cortex white matter. Adverse rearing in monkeys persistently impaired frontal white matter tract integrity, a novel substrate for understanding affective susceptibility.

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KW - Fractional anisotropy

KW - Variable foraging demand

KW - White matter integrity

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The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates

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