The role of E3 ubiquitin ligase smurfs in BMP and TGF-beta signaling in bone cells

Qing Wang, Tian Hui Zhu, Ming Zhang, Di Chen

Research output: Contribution to journalReview article

Abstract

The ubiquitin-proteasome system is composed by multiple enzymes which are ubiquitously expressed in mammalian cells and plays an essential role in a variety of biological processes. As key members of the protein degradation enzymatic system, the function of E3 ubiquitin ligases has been extensively investigated. BMP and TGF-β are critical molecules that regulate proliferation, differentiation and apoptosis of osteoblasts and chondrocytes through different signaling pathways. Resent findings indicate that the ubiquitin-proteasome system functions as a key regulator in bone cells and the E3 ligase mediates the proteolytic degradation of critical molecules in BMP and TGF-β signaling pathways. Recent progress on studies of HECT domain E3 ligase, Smurf, in osteoblasts and chondrocytes were summarized. The regulatory role of Smurf1 and Smurf2 in BMP and TGF-β signaling and osteoblast and chondrocyte function has been reviewed.

Original languageEnglish (US)
Pages (from-to)423-430
Number of pages8
JournalProgress in Biochemistry and Biophysics
Volume33
Issue number5
Publication statusPublished - May 1 2006
Externally publishedYes

    Fingerprint

Keywords

  • Bone morphogenetic proteins (BMPs)
  • Chondrocyte
  • E3 ubiquitin ligase
  • Osteoblast
  • Smurf
  • Transforming growth factor-β (TGF-β)
  • Ubiquitin-proteasome system

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this