The role of DNA synthesis imaging in cancer in the era of targeted therapeutics

Sridhar Nimmagadda, Anthony F. Shields

Research output: Contribution to journalReview articlepeer-review

Abstract

Non-specific targets such as DNA and microtubules have been the mainstay of cancer therapeutics and the most effective clinical agents until a decade ago. Advances in genetics, molecular and cellular biology over the past decade led to the development of a new generation of agents that are far more specific and effective. In contrast to progress seen with therapeutic agents, general monitoring targets such as proliferation imaging are just gaining momentum and targeted imaging is still in its infancy. In these paradoxical times, this review assesses the role of proliferation imaging in monitoring the efficacy of targeted therapeutics.

Original languageEnglish (US)
Pages (from-to)575-587
Number of pages13
JournalCancer and Metastasis Reviews
Volume27
Issue number4
DOIs
StatePublished - Dec 2008

Keywords

  • DNA synthesis
  • FAU
  • FBAU
  • FMAU
  • Proliferation
  • Thymidine
  • Thymidine kinase
  • Thymidine phosphorylase
  • Thymidylate synthase

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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