The role of copper chaperone atox1 in coupling redox homeostasis to intracellular copper distribution

Yuta Hatori, Svetlana Lutsenko

Research output: Contribution to journalReview article

Abstract

Human antioxidant protein 1 (Atox1) is a small cytosolic protein with an essential role in copper homeostasis. Atox1 functions as a copper carrier facilitating copper transfer to the secretory pathway. This process is required for activation of copper dependent enzymes involved in neurotransmitter biosynthesis, iron efflux, neovascularization, wound healing, and regulation of blood pressure. Recently, new cellular roles for Atox1 have emerged. Changing levels of Atox1 were shown to modulate response to cancer therapies, contribute to inflammatory response, and protect cells against various oxidative stresses. It has also become apparent that the activity of Atox1 is tightly linked to the cellular redox status. In this review, we summarize biochemical information related to a dual role of Atox1 as a copper chaperone and an antioxidant. We discuss how these two activities could be linked and contribute to establishing the intracellular copper balance and functional identity of cells during differentiation.

Original languageEnglish (US)
Article number25
JournalAntioxidants
Volume5
Issue number3
DOIs
StatePublished - Sep 2016

Keywords

  • Atox1
  • Copper
  • Copper chaperone
  • Glutathione
  • Heavy metal

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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