TY - JOUR
T1 - The role of chemokines in human immunodeficiency virus infection
AU - Garzino-Demo, Alfredo
AU - DeVico, Anthony L.
AU - Conant, Katherine E.
AU - Gallo, Robert C.
PY - 2000
Y1 - 2000
N2 - Chemokines that bind to human immunodeficiency virus (HIV) co-receptors are potent and selective inhibitors of HIV infection. Therefore, ever since our discovery of this activity, we have proposed their role in controlling HIV infection as a third arm of the immune response, i.e. in concert with humoral and cellular responses. Research carried out in our laboratory, and performed independently by other groups, has recently strengthened this concept. Here, we critically analyze the evidence indicating the positive contribution of chemokines to HIV infection, their involvement with cognate and innate immunity, and the potential for their use in combating HIV infection.
AB - Chemokines that bind to human immunodeficiency virus (HIV) co-receptors are potent and selective inhibitors of HIV infection. Therefore, ever since our discovery of this activity, we have proposed their role in controlling HIV infection as a third arm of the immune response, i.e. in concert with humoral and cellular responses. Research carried out in our laboratory, and performed independently by other groups, has recently strengthened this concept. Here, we critically analyze the evidence indicating the positive contribution of chemokines to HIV infection, their involvement with cognate and innate immunity, and the potential for their use in combating HIV infection.
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U2 - 10.1034/j.1600-065X.2000.17711.x
DO - 10.1034/j.1600-065X.2000.17711.x
M3 - Review article
C2 - 11138787
AN - SCOPUS:0033647215
SN - 0105-2896
VL - 177
SP - 79
EP - 87
JO - Immunological reviews
JF - Immunological reviews
ER -