The role of CD4+ T cell responses in antitumor immunity

Research output: Contribution to journalArticlepeer-review


While most of the focus in cancer immunology is on CD8+ cytotoxic T lymphocyte responses, recent evidence indicates that CD4+ T cells are an equally critical component of the antitumor immune response. Successful immunity to cancer will therefore require activation of tumor-specific CD4+ T cells. Tumor antigens recognized by CD4+ T cells that are restricted by MHC class II are beginning to be defined in both murine and human tumors. These will provide the basis for new generations of antigen-specific tumor vaccines.

Original languageEnglish (US)
Pages (from-to)588-594
Number of pages7
JournalCurrent Opinion in Immunology
Issue number5
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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