Abstract
The role of cation-π and electrostatic bonding in noncovalent interactions was discussed. The cation-π interactions have been implicated in the binding of Ach and other choline derivatives to the nicotinic receptor. It was shown that chlorisondamine (CHL) forms noncovalent complexes with phosphorylated and acidic amino acid residues of peptides (P) as well as certain lipids through electrostatic interaction between quaternary ammonium (QA) and acidic or phosphorylated residues, using various peptides. The addition of ACh to P3 and P4 which contain respectively a phosphorylated Thr and 6 Glu (P3) and a phosphorylated Ser and 6 Glu (P4), resulted in the non-covalent addition of 6 ACh to each peptide.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics |
| Pages | 479-480 |
| Number of pages | 2 |
| State | Published - 2002 |
| Externally published | Yes |
| Event | Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duration: Jun 2 2002 → Jun 6 2002 |
Other
| Other | Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics |
|---|---|
| Country/Territory | United States |
| City | Orlando, FL |
| Period | 6/2/02 → 6/6/02 |
ASJC Scopus subject areas
- Spectroscopy