The role of cation-π and electrostatic bonding in noncovalent interactions

Amina S. Woods

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The role of cation-π and electrostatic bonding in noncovalent interactions was discussed. The cation-π interactions have been implicated in the binding of Ach and other choline derivatives to the nicotinic receptor. It was shown that chlorisondamine (CHL) forms noncovalent complexes with phosphorylated and acidic amino acid residues of peptides (P) as well as certain lipids through electrostatic interaction between quaternary ammonium (QA) and acidic or phosphorylated residues, using various peptides. The addition of ACh to P3 and P4 which contain respectively a phosphorylated Thr and 6 Glu (P3) and a phosphorylated Ser and 6 Glu (P4), resulted in the non-covalent addition of 6 ACh to each peptide.

Original languageEnglish (US)
Title of host publicationProceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
Pages479-480
Number of pages2
StatePublished - 2002
Externally publishedYes
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

ASJC Scopus subject areas

  • Spectroscopy

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  • Cite this

    Woods, A. S. (2002). The role of cation-π and electrostatic bonding in noncovalent interactions. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics (pp. 479-480)