The role of calmodulin kinase II in myocardial physiology and disease

Luis F. Couchonnal, Mark E. Anderson

Research output: Contribution to journalReview articlepeer-review

Abstract

The multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates a rich variety of downstream targets in heart. Ca 2+ homeostatic proteins are important CaMKII targets that support myocardial excitation-contraction coupling. Under stress conditions, excessive CaMKII activity promotes heart failure and arrhythmias, in part through actions at Ca2+ homeostatic proteins. Here, we briefly review the molecular and cellular physiology of CaMKII in myocardium.

Original languageEnglish (US)
Pages (from-to)151-159
Number of pages9
JournalPhysiology
Volume23
Issue number3
DOIs
StatePublished - Jun 2008
Externally publishedYes

ASJC Scopus subject areas

  • Physiology

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