The role of calcium in the regulation of apoptosis

David J. McConkey; Sten Orrenius

doi:10.1002/jlb.59.6.775

The role of calcium in the regulation of apoptosis

David J. McConkey, Sten Orrenius

Research output: Contribution to journal › Review article › peer-review

218 Scopus citations

Abstract

The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegans to humans suggests that a conserved set of biochemical mechanism(s) may also be involved in the response. Work from a number of independent laboratories suggests that alterations in cytosolic Ca²⁺ homeostasis represent one such candidate mechanism, and molecular targets for Ca²⁺ are now being identified. This review will summarize what is known about the role of Ca²⁺ in the regulation of apoptosis and discuss how Ca²⁺ might interact with some of the other biochemical signals implicated in cell death.

Original language	English (US)
Pages (from-to)	775-783
Number of pages	9
Journal	Journal of Leukocyte Biology
Volume	59
Issue number	6
DOIs	https://doi.org/10.1002/jlb.59.6.775
State	Published - Jun 1996
Externally published	Yes

Keywords

BCL-2
Endonuclease
Oxidative stress

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Cell Biology

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10.1002/jlb.59.6.775

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abstract = "The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegans to humans suggests that a conserved set of biochemical mechanism(s) may also be involved in the response. Work from a number of independent laboratories suggests that alterations in cytosolic Ca2+ homeostasis represent one such candidate mechanism, and molecular targets for Ca2+ are now being identified. This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss how Ca2+ might interact with some of the other biochemical signals implicated in cell death.",

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AU - Orrenius, Sten

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AB - The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegans to humans suggests that a conserved set of biochemical mechanism(s) may also be involved in the response. Work from a number of independent laboratories suggests that alterations in cytosolic Ca2+ homeostasis represent one such candidate mechanism, and molecular targets for Ca2+ are now being identified. This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss how Ca2+ might interact with some of the other biochemical signals implicated in cell death.

KW - BCL-2

KW - Endonuclease

KW - Oxidative stress

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JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

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The role of calcium in the regulation of apoptosis

Abstract

Keywords

ASJC Scopus subject areas

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