The role of calcium in the regulation of apoptosis

David J. McConkey; Sten Orrenius

doi:10.1006/bbrc.1997.7409

The role of calcium in the regulation of apoptosis

David J. McConkey, Sten Orrenius

Research output: Contribution to journal › Review article › peer-review

369 Scopus citations

Abstract

Apoptosis (programmed cell death) has gained widespread attention due to its roles in a variety of physiological and pathological processes, yet precisely how apoptosis is regulated by external and internal cues remains unclear. Work from our laboratories and others has implicated alterations in intracellular Ca²⁺ in apoptosis, and more recent work has defined particular biochemical processes that are targeted by Ca²⁺ in apoptotic cells. This review will summarize the role of Ca²⁺ in apoptosis within the context of what is known about the core components of the effector machinery for apoptosis.

Original language	English (US)
Pages (from-to)	357-366
Number of pages	10
Journal	Biochemical and Biophysical Research Communications
Volume	239
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1997.7409
State	Published - Oct 20 1997
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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The role of calcium in the regulation of apoptosis

Abstract

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