The role of c-Jun N-terminal Kinase (JNK) in retinal degeneration and vision loss

Byung Jin Kim, Donald J. Zack

Research output: Chapter in Book/Report/Conference proceedingChapter


c-Jun N-terminal kinase (JNK), a member of stress-induced mitogen-activated protein (MAP) kinase family, has been shown to modulate a variety of biological processes associated with neurodegenerative pathology of the retina. In particular, various retinal cell culture and animal models related to glaucoma, age-related macular degeneration (AMD), and retinitis pigmentosa indicate that JNK signaling may contribute to disease pathogenesis. This mini-review discusses the impact of JNK signaling in retinal disease, with a focus on retinal ganglion cells (RGCs), photoreceptor cells, retinal pigment epithelial (RPE) cells, and animal studies, with particular attention to modulation of JNK signaling as a potential therapeutic target for the treatment of retinal disease.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages7
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Age-related macular degeneration (AMD)
  • c-Jun N-terminal Kinase (JNK)
  • Optic neuropathy
  • Photoreceptor cells
  • Retinal degeneration
  • Retinal ganglion cell (RGC)
  • Retinal pigmented epithelial (RPE) cell
  • Retinitis pigmentosa
  • Therapeutic target

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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