The role of blood pressure as a risk factor for renal disease: A review of the epidemiologic evidence

P. K. Whelton, T. V. Perneger, J. He, M. J. Klag

Research output: Contribution to journalArticlepeer-review


The aim of the paper is to examine the relationship between blood pressure (BP) and renal disease with an overview of observational and experimental investigations, with the emphasis on studies that provide data obtained in unselected population samples. We have found an increasing body of evidence from cross-sectional, case-control, prospective, and experimental studies that indicate BP is an important, independent predictor of both increased relative and attributable risk of renal insufficiency and end-stage renal disease. The relationship between BP and subsequent renal disease appears to be positive and continuous throughout the entire range of BP. Furthermore, the data indicate that elevations in systolic BP (SBP) are stronger predictors of risk compared to corresponding increases in diastolic BP (DBP). Clinical trials experience suggests that reduction in BP decreases the risk of subsequent renal disease. Ongoing trials should help to clarify issues related to choice of antihypertensive therapy and optimal goals for reduction of BP in order to prevent renal disease.

Original languageEnglish (US)
Pages (from-to)683-689
Number of pages7
JournalJournal of Human Hypertension
Issue number10
StatePublished - Jun 28 1996


  • Blood pressure
  • End-stage renal disease
  • Epidemiology
  • Prevention
  • Renal disease

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'The role of blood pressure as a risk factor for renal disease: A review of the epidemiologic evidence'. Together they form a unique fingerprint.

Cite this