The role of ATP-dependent machines in regulating genome topology

Research output: Contribution to journalReview articlepeer-review


All cells must copy and express genes in accord with internal and external cues. The proper timing and response of such events relies on the active control of higher-order genomic organization. Cells use ATP-dependent molecular machines to alter the local and global topology of DNA so as to promote and counteract the persistent effects of transcription and replication. X-ray crystallography and electron microscopy, coupled with biochemical and single molecule methods are continuing to provide a wealth of mechanistic information on how DNA remodeling factors are employed to dynamically shape and organize the genome.

Original languageEnglish (US)
Pages (from-to)85-96
Number of pages12
JournalCurrent Opinion in Structural Biology
StatePublished - Feb 1 2016

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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