The Role of ARV Associated Adverse Drug Reactions in Influencing Adherence Among HIV-Infected Individuals: A Systematic Review and Qualitative Meta-Synthesis

Haochu Li, Gifty Marley, Wei Ma, Chongyi Wei, Mellanye Lackey, Qingyan Ma, Françoise Renaud, Marco Vitoria, Rachel Beanland, Meg Caroline Doherty, Joseph D. Tucker

Research output: Contribution to journalArticle

Abstract

Poor adherence remains a major barrier to achieving the clinical and public health benefits of antiretroviral drugs (ARVs). A systematic review and qualitative meta-synthesis was conduct to evaluate how ARV adverse drug reactions may influence ARV adherence. Thirty-nine articles were identified, and 33 reported that ARV adverse drug reactions decreased adherence and six studies found no influence. Visually noticeable adverse drug reactions and psychological adverse reactions were reported as more likely to cause non-adherence compared to other adverse drug reactions. Six studies reported a range of adverse reactions associated with EFV-containing regimens contributing to decreased adherence. Informing HIV-infected individuals about ARV adverse drug reactions prior to initiation, counselling about coping mechanisms, and experiencing the effectiveness of ARVs on wellbeing may improve ARV adherence.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalAIDS and Behavior
DOIs
StateAccepted/In press - Sep 9 2016
Externally publishedYes

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Drug-Related Side Effects and Adverse Reactions
HIV
Insurance Benefits
Counseling
Public Health
Psychology
Pharmaceutical Preparations

Keywords

  • Adherence
  • Adverse drug reaction
  • Antiretroviral
  • HIV
  • Qualitative meta-synthesis

ASJC Scopus subject areas

  • Social Psychology
  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

The Role of ARV Associated Adverse Drug Reactions in Influencing Adherence Among HIV-Infected Individuals : A Systematic Review and Qualitative Meta-Synthesis. / Li, Haochu; Marley, Gifty; Ma, Wei; Wei, Chongyi; Lackey, Mellanye; Ma, Qingyan; Renaud, Françoise; Vitoria, Marco; Beanland, Rachel; Doherty, Meg Caroline; Tucker, Joseph D.

In: AIDS and Behavior, 09.09.2016, p. 1-11.

Research output: Contribution to journalArticle

Li, Haochu ; Marley, Gifty ; Ma, Wei ; Wei, Chongyi ; Lackey, Mellanye ; Ma, Qingyan ; Renaud, Françoise ; Vitoria, Marco ; Beanland, Rachel ; Doherty, Meg Caroline ; Tucker, Joseph D. / The Role of ARV Associated Adverse Drug Reactions in Influencing Adherence Among HIV-Infected Individuals : A Systematic Review and Qualitative Meta-Synthesis. In: AIDS and Behavior. 2016 ; pp. 1-11.
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