The role of adiponectin in reproduction

From polycystic ovary syndrome to assisted reproduction

Konstantinos G. Michalakis, James Segars

Research output: Contribution to journalArticle

Abstract

Objective: To summarize the effects of the adipokine adiponectin on the reproductive endocrine system, from the hypothalamic-pituitary axis to the gonads and target tissues of the reproductive system. Design: A Medline computer search was performed to identify relevant articles. Setting: Research institution. Intervention(s): None. Result(s): Adiponectin is a hormone secreted by adipose tissue that acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other tissues. Adiponectin mediates its actions in the periphery mainly via two receptors, AdipoR1 and AdipoR2. Adiponectin receptors are present in many reproductive tissues, including the central nervous system, ovaries, oviduct, endometrium, and testes. Adiponectin influences gonadotropin release, normal pregnancy, and assisted reproduction outcomes. Conclusion(s): Adiponectin, a beneficial adipokine, represents a major link between obesity and reproduction. Higher levels of adiponectin are associated with improved menstrual function and better outcomes in assisted reproductive cycles.

Original languageEnglish (US)
Pages (from-to)1949-1957
Number of pages9
JournalFertility and Sterility
Volume94
Issue number6
DOIs
StatePublished - Nov 2010
Externally publishedYes

Fingerprint

Polycystic Ovary Syndrome
Adiponectin
Reproduction
Adipokines
Adiponectin Receptors
Endocrine System
Oviducts
Gonads
Endometrium
Gonadotropins
Insulin Resistance
Adipose Tissue
Testis
Ovary
Central Nervous System
Obesity
Hormones
Pregnancy
Research

Keywords

  • Adiponectin
  • assisted reproduction
  • embryo development
  • gonads
  • hypothalamus
  • PCOS
  • pituitary
  • polycystic ovary syndrome
  • pregnancy
  • reproduction

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

The role of adiponectin in reproduction : From polycystic ovary syndrome to assisted reproduction. / Michalakis, Konstantinos G.; Segars, James.

In: Fertility and Sterility, Vol. 94, No. 6, 11.2010, p. 1949-1957.

Research output: Contribution to journalArticle

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