The role of αA-crystallin in experimental autoimmune uveitis

L. Wang; L. Zhang; Z. F. Wang; Z. X. Huang; X. Hu; L. Gong; X. Tang; F. Liu; Z. Luo; W. Ji; W. F. Hu; Z. Woodward; J. Zhu; Y. Z. Liu; Q. D. Nguyen; D. W.C. Li

doi:10.2174/1566524015666150731101146

The role of αA-crystallin in experimental autoimmune uveitis

L. Wang, L. Zhang, Z. F. Wang, Z. X. Huang, X. Hu, L. Gong, X. Tang, F. Liu, Z. Luo, W. Ji, W. F. Hu, Z. Woodward, J. Zhu, Y. Z. Liu, Q. D. Nguyen, D. W.C. Li

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Uveitis refers to a group of ocular inflammatory diseases that can lead to blindness. For years, researchers have been trying to decipher the underlying mechanisms and develop therapeutic strategies using the model of experimental autoimmune uveitis (EAU). Recently, αA-crystallin has been found to be upregulated in EAU and can even ameliorate its severity through different mechanisms, suggesting its use as a potent therapeutic factor against uveitis. Here we review the protective role of αA-crystallin and discuss its functional mechanisms in EAU.

Original language	English (US)
Pages (from-to)	558-564
Number of pages	7
Journal	Current Molecular Medicine
Volume	15
Issue number	6
DOIs	https://doi.org/10.2174/1566524015666150731101146
State	Published - Aug 1 2015

Keywords

Experimental autoimmune uveitis
Gene therapy
Uveitis
αA-crystallin

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology

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10.2174/1566524015666150731101146

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title = "The role of αA-crystallin in experimental autoimmune uveitis",

abstract = "Uveitis refers to a group of ocular inflammatory diseases that can lead to blindness. For years, researchers have been trying to decipher the underlying mechanisms and develop therapeutic strategies using the model of experimental autoimmune uveitis (EAU). Recently, αA-crystallin has been found to be upregulated in EAU and can even ameliorate its severity through different mechanisms, suggesting its use as a potent therapeutic factor against uveitis. Here we review the protective role of αA-crystallin and discuss its functional mechanisms in EAU.",

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doi = "10.2174/1566524015666150731101146",

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AU - Zhang, L.

AU - Wang, Z. F.

AU - Huang, Z. X.

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AU - Gong, L.

AU - Tang, X.

AU - Liu, F.

AU - Luo, Z.

AU - Ji, W.

AU - Hu, W. F.

AU - Woodward, Z.

AU - Zhu, J.

AU - Liu, Y. Z.

AU - Nguyen, Q. D.

AU - Li, D. W.C.

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AB - Uveitis refers to a group of ocular inflammatory diseases that can lead to blindness. For years, researchers have been trying to decipher the underlying mechanisms and develop therapeutic strategies using the model of experimental autoimmune uveitis (EAU). Recently, αA-crystallin has been found to be upregulated in EAU and can even ameliorate its severity through different mechanisms, suggesting its use as a potent therapeutic factor against uveitis. Here we review the protective role of αA-crystallin and discuss its functional mechanisms in EAU.

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The role of αA-crystallin in experimental autoimmune uveitis

Abstract

Keywords

ASJC Scopus subject areas

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