The role for interleukin-12 therapy of cutaneous T cell lymphoma

Alain H. Rook, Mohamed H. Zaki, Maria Wysocka, Gary S. Wood, Madeleine Duvic, Louise C. Showe, Francine Foss, Michael Shapiro, Timothy M. Kuzel, Elise A. Olsen, Eric C. Vonderheid, Robert Laliberte, Matthew L. Sherman

Research output: Contribution to journalArticle

Abstract

Recent phase I and phase II trials using recombinant human interleukin-12 (rhIL-12) for cutaneous T cell lymphoma (CTCL) have been completed. Observations on 32 evaluable patients revealed an overall response rate approaching 50 percent. Biopsy of regressing lesions revealed an increase in numbers of CD8+ and/or TIA-1+ T cells. These results suggest that rhIL-12 may induce lesion regression by augmenting antitumor cytotoxic T cell responses. Future trials will be focused on strategies for further immune enhancement by the concomitant use of additional immune augmenting cytokines with rhIL-12.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume941
StatePublished - 2001
Externally publishedYes

    Fingerprint

Keywords

  • Interferon-γ
  • Interleukin-2
  • Recombinant human interleukin-12

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rook, A. H., Zaki, M. H., Wysocka, M., Wood, G. S., Duvic, M., Showe, L. C., Foss, F., Shapiro, M., Kuzel, T. M., Olsen, E. A., Vonderheid, E. C., Laliberte, R., & Sherman, M. L. (2001). The role for interleukin-12 therapy of cutaneous T cell lymphoma. Annals of the New York Academy of Sciences, 941, 177-184.