The risk of fall and fracture with the initiation of a prostate-selective α antagonist: A population based cohort Study

Blayne Welk, Eric McArthur, Lisa Ann Fraser, Jade Hayward, Stephanie Dixon, Y. Joseph Hwang, Michael Ordon

Research output: Contribution to journalArticlepeer-review

Abstract

STUDY QUESTION: Do men starting treatment with prostate-specific α antagonists have increased risk of fall and fracture? METHODS: Administrative datasets from the province of Ontario, Canada, that contain patient level data were used to generate a cohort of 147 084 men aged ≥66 years who flled their frst outpatient prescription for prostatespecific α antagonists tamsulosin, alfuzosin, or silodosin between June 2003 and December 2013 (exposed men) plus an equal sized cohort matched 1:1 (using a propensity score model) who did not initiate α antagonist therapy. The primary outcome was a hospital emergency room visit or inpatient admission for a fall or fracture in the 90 days afer exposure. STUDY ANSWER AND LIMITATIONS: The men exposed to prostate-specific α antagonist had significantly increased risks of falling (odds ratio 1.14 (95% CI 1.07 to 1.21), absolute risk increase 0.17% (0.08 to 0.25%)) and of sustaining a fracture (odds ratio 1.16 (1.04 to 1.29), absolute risk increase 0.06% (0.02 to 0.11%)) compared with the unexposed cohort. This increased risk was not observed in the period before α antagonist use. Secondary outcomes of hypotension and head trauma were also significantly increased in the exposed cohort (odds ratios 1.80 (1.59 to 2.03) and 1.15 (1.04 to 1.27) respectively). The two cohorts were similar across 98 diferent covariates including demographics, comorbid conditions, medication use, healthcare use, and prior medical investigation. Potential unmeasured confounders, such as physical deconditioning, mobility impairment, and situational risk factors, may exist. The data used to identify the primary outcomes had limited sensitivity, so the absolute risks of the outcomes are probably underestimates. The study only included men >66 years old, and 84% of exposed men were prescribed tamsulosin, so results may not be generalizable to younger men, and there may not be statistical power to show small diferences in outcomes between the drugs. WHAT THIS STUDY ADDS: Prostate-specific a antagonists are associated with a small but significant increased risk of fall, fracture, and head trauma, probably as a result of induced hypotension. FUNDING, COMPETING INTERESTS, DATA SHARING: This project was conducted at the Institute for Clinical Evaluative Sciences (ICES) Western Site through the Kidney, Dialysis, and Transplantation (KDT) research program. BW has received a research grantfrom Astellas, and L-AF does consultancy for Amgen.

Original languageEnglish (US)
Article numberh5398
JournalBMJ (Online)
Volume351
DOIs
StatePublished - Oct 26 2015
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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