TY - JOUR
T1 - The retinoblastoma gene
T2 - A prototypic and multifunctional tumor suppressor
AU - Zheng, Lei
AU - Lee, Wen Hwa
N1 - Funding Information:
We are indebted to Drs. Nickolas Ting, Tom Boyer, and Paul Hasty for their critical reading of this manuscript and their constructive comments. We also thank Drs. Phang-Lang Chen and Yumay Chen for many inspiring discussion. We apologize to our colleagues whose work was not cited because of space limitation. This work was supported by NIH grants (EY05758 and CA58318) and Alice P. McDermott endowment funds to W.-H.L.
PY - 2001/3/10
Y1 - 2001/3/10
N2 - Genome instability has been implicated in the generation of multiple somatic mutations that underlie cancer. Germline mutation in the retinoblastoma (RB) gene leads to tumor formation in both human and experimental animal models, and reintroduction of wild-type RB is able to suppress neoplastic phenotypes. Rb governs the passage of cells through the G1 phase-restriction point and this control is lost in most cancer cells. Rb has also been shown to promote terminal differentiation and prevent cell cycle reentry. Recent studies implicate Rb in mitotic progression, faithful chromosome segregation, checkpoint control, and chromatin remodeling, suggesting that Rb may function in the maintenance of genome integrity. It is likely that Rb suppresses tumor formation by virtue of its multiple biological activities. A single protein capable of performing multiple antioncogenic functions may be a common characteristic of other tumor suppressors including p53 and BRCA1/2.
AB - Genome instability has been implicated in the generation of multiple somatic mutations that underlie cancer. Germline mutation in the retinoblastoma (RB) gene leads to tumor formation in both human and experimental animal models, and reintroduction of wild-type RB is able to suppress neoplastic phenotypes. Rb governs the passage of cells through the G1 phase-restriction point and this control is lost in most cancer cells. Rb has also been shown to promote terminal differentiation and prevent cell cycle reentry. Recent studies implicate Rb in mitotic progression, faithful chromosome segregation, checkpoint control, and chromatin remodeling, suggesting that Rb may function in the maintenance of genome integrity. It is likely that Rb suppresses tumor formation by virtue of its multiple biological activities. A single protein capable of performing multiple antioncogenic functions may be a common characteristic of other tumor suppressors including p53 and BRCA1/2.
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U2 - 10.1006/excr.2000.5129
DO - 10.1006/excr.2000.5129
M3 - Article
C2 - 11237519
AN - SCOPUS:0035835815
VL - 264
SP - 2
EP - 18
JO - Experimental Cell Research
JF - Experimental Cell Research
SN - 0014-4827
IS - 1
ER -