The retinal oxysterol pathway: A unifying hypothesis for the cause of aqe-related macular degeneration

Norman B. Javitt, Jonathan C. Javitt

Research output: Contribution to journalArticlepeer-review

Abstract

The toxic role of 7-ketocholesterol and existing pathways for its neutralization may point the way to a unified theory that explains the cause of age-related macular degeneration and points towards novel therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalCurrent Opinion in Ophthalmology
Volume20
Issue number3
DOIs
StatePublished - May 2009

Keywords

  • Age-related macular degeneration
  • Ketocholesterol
  • Light toxicity
  • Oxysterol
  • Photooxidation

ASJC Scopus subject areas

  • Ophthalmology

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