The response of osteoblast-like cells to dexamethasone and cyclic loading

Lynne C. Jones, Brian Yeoumans, David S. Hungerford, Carmelita G. Frondoza

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to investigate whether cyclic loading can alter the response of osteoblasts to dexamethasone. Proliferation of osteoblast-like cells (MG-63) was assessed by determining uptake of 3H-thymidine. Three doses of dexamethasone were tested: 0.001nM, .001nM, or 0.1nM. Exposure to increasing levels of dexamethasone resulted in decreased proliferation of osteoblast-like cells. Although there was a slight decrease in proliferation seen in the controls (no dexamethasone) with cyclic loading, cyclic loading did not affect the response of osteoblast-like cells to dexamethasone under these test conditions. Varying loading conditions and the potential effect on metabolic and synthetic activity of the osteoblast-like cells need further study.

Original languageEnglish (US)
Pages (from-to)273-277
Number of pages5
JournalBiomedical Sciences Instrumentation
Volume42
StatePublished - Apr 1 2006

Keywords

  • Cellular response
  • Cyclic tensile strain
  • Osteoblasts
  • Osteonecrosis
  • Osteoporosis

ASJC Scopus subject areas

  • Biophysics
  • Medical Laboratory Technology

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