The response of osteoblast-like cells to dexamethasone and cyclic loading

Lynne C. Jones, Brian Yeoumans, David S. Hungerford, Carmelita G. Frondoza

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aim of this study was to investigate whether cyclic loading can alter the response of osteoblasts to dexamethasone. Proliferation of osteoblast-like cells (MG-63) was assessed by determining uptake of 3H-thymidine. Three doses of dexamethasone were tested: 0.00InM, .OOlnM, or O.lnM. Exposure to increasing levels of dexamethasone resulted in decreased proliferation of osteoblast-like cells. Although there was a slight decrease in proliferation seen in the controls (no dexamethasone) with cyclic loading, cyclic loading did not affect the response of osteoblast-like cells to dexamethasone under these test conditions. Varying loading conditions and the potential effect on metabolic and synthetic activity of the osteoblast-like cells need further study.

Original languageEnglish (US)
Title of host publicationTechnical Papers of ISA
Pages273-277
Number of pages5
Volume464
Publication statusPublished - 2006
Event43rd Annual Rocky Mountain Bioengineering Symposium and 43rd International ISA Biomedical Sciences Instrumentation Symposium - Terre Haute, IN, United States
Duration: Apr 7 2006Apr 9 2006

Other

Other43rd Annual Rocky Mountain Bioengineering Symposium and 43rd International ISA Biomedical Sciences Instrumentation Symposium
CountryUnited States
CityTerre Haute, IN
Period4/7/064/9/06

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Keywords

  • Cellular response
  • Cyclic tensile strain
  • Osteoblasts
  • Osteonecrosis
  • Osteoporosis

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering
  • Computer Science Applications

Cite this

Jones, L. C., Yeoumans, B., Hungerford, D. S., & Frondoza, C. G. (2006). The response of osteoblast-like cells to dexamethasone and cyclic loading. In Technical Papers of ISA (Vol. 464, pp. 273-277)