The release of chromatin template restrictions by natural polyribonucleotides

David G. Brown, Donald S. Coffey

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Certain natural RNAs are capable of releasing the DNA template restrictions on soluble rat liver chromatin, when assayed with an excess of exogenous DNA polymerase. A marked difference in the capacity for DNA template activation was observed among the RNAs isolated from yeast, Escherichia coli, rat liver and MS-2 and Qβ bacteriophages. The effects observed with the natural RNAs were compared with several synthetic polyribonucleotides.

Original languageEnglish (US)
Pages (from-to)326-333
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Jan 22 1971

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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