The relative impact of vision impairment and cardiovascular disease on quality of life: The example of pseudoxanthoma elasticum

Robert P. Finger, Eva Fenwick, Manjula Marella, Peter Charbel Issa, Hendrik P.N. Scholl, Frank G. Holz, Ecosse L. Lamoureux

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate the impact of pseudoxanthoma elasticum (PXE), a rare hereditary disease of concurrent vision impairment (VI) and cardiovascular complications (CVCs), on vision-related (VRQoL) and health-related quality of life (HRQoL).Methods: VRQoL and HRQoL were assessed using the Impact of Vision Impairment (IVI) questionnaire and the Short Form Health Survey (SF-36) in 107 PXE patients. Patients were stratified into four groups: A = no VI or CVC; B = CVCs only; C = VI only; and D = both VI and CVCs.Results: Following Rasch analysis, the IVI was found to function as a vision-specific functioning and emotional well-being subscale, and the SF-36 as a health-related physical functioning and mental health subscale. The presence of VI and CVC were significant predictors of vision-specific functioning and emotional well-being (p < 0.001), with a clinically meaningful decrement in vision-specific functioning in patients with VI. No associations were found for the SF-36 Physical Functioning and Mental Health scores between any groups.Conclusions: Vision impaired patients with PXE report significantly poorer vision-specific functioning than PXE patients without VI. In contrast, the relative impact of PXE on reported general HRQoL was much less. Our results suggest that vision impairment has the larger impact on QoL in this sample.

Original languageEnglish (US)
Article number113
JournalHealth and Quality of Life Outcomes
Volume9
DOIs
StatePublished - Dec 12 2011

Keywords

  • Cardiovascular disease
  • Health-related quality of life (HRQol)
  • Impact of vision impairment questionnaire (IVI)
  • Pseudoxanthoma elasticum (PXE)
  • SF-36
  • Vision-related quality of life (VRQol)
  • Visual impairment

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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