Abstract
Context: Clinical study of breast cancer patients in Chicago, IL, USA. Objective: Ascertain the utility of measurements of single-strand breaks (SSB) in DNA for assessment of breast cancer risk. Methods: Fine-needle aspirates of the breast, SSB by nick translation, percent breast density (PBD), Gail model risk, cumulative methylation index (CMI), enzymes of DNA repair and tissue antioxidants. Results: DNA repair enzymes and 4-hydroxyestradiol were negatively associated with SSB; CMI and PBD were positively associated. Conclusions: Quantitative measurement of SSBs by this procedure indicates the relative number of SSBs and is related to promoter methylation, antioxidant availability and percent breast density.
Original language | English (US) |
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Pages (from-to) | 689-697 |
Number of pages | 9 |
Journal | Biomarkers |
Volume | 22 |
Issue number | 7 |
DOIs | |
State | Published - Oct 3 2017 |
Keywords
- Breast cancer
- DNA methylation
- breast cancer risk
- single-strand breaks in DNA
- tissue oestrogens
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis