TY - JOUR
T1 - The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smoking
AU - Venarske, Daniel L.
AU - Busse, William W.
AU - Griffin, Marie R.
AU - Gebretsadik, Tebeb
AU - Shintani, Ayumi K.
AU - Minton, Patricia A.
AU - Peebles, R. Stokes
AU - Hamilton, Robert
AU - Weisshaar, Elizabeth
AU - Vrtis, Rose
AU - Higgins, Stanley B.
AU - Hartert, Tina V.
N1 - Funding Information:
Financial support: National Institutes of Health (grants 5 R01 AI054660 and 5 R01 HL069949 to R.S.P.; grants KO8 AI01582, MO1 RR00095, UO1 HL72471, and R01 AI50884 to T.V.H.); American Lung Association (Clinical Research Grant to T.V.H.).
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Background. Although rhinovirus (RV) respiratory infections trigger asthma exacerbations, the etiologic association between this virus and severe exacerbations, as well as the clinical characteristics of adults at risk for RV-associated asthma that necessitates hospitalization, have not been established. Methods. During 1999-2003, we conducted a cohort study of 101 adults prospectively enrolled at hospital admission for an asthma exacerbation. Patient characteristics and frequencies of RV in nasal specimens were analyzed, by reverse-transcription polymerase chain reaction (RT-PCR), at asthma-related hospital admission and at a 3-month convalescent follow-up visit. Results. RV was detected by RT-PCR in 21% of hospitalized patients over a 4-year period and in 1.3% of patients who returned for a 3-month follow-up visit. RV detection was strongly associated with hospitalization for asthma (adjusted odds ratio [OR], 15.1 [95% confidence interval {CI}, 1.88-121.4]). After adjustment for baseline asthma severity, RV-positive patients were more likely than RV-negative patients to be current smokers and nonusers of inhaled corticosteroids (ICSs) (adjusted OR, 11.18 [95% CI, 2.37-52.81]; P = .002). Conclusions. RV respiratory infection is an etiologic agent in severe asthma exacerbations necessitating hospitalization in adults. Compared with hospitalized patients with asthma who were RV negative, RV-positive patients were significantly more likely to be smokers and nonusers of ICSs.
AB - Background. Although rhinovirus (RV) respiratory infections trigger asthma exacerbations, the etiologic association between this virus and severe exacerbations, as well as the clinical characteristics of adults at risk for RV-associated asthma that necessitates hospitalization, have not been established. Methods. During 1999-2003, we conducted a cohort study of 101 adults prospectively enrolled at hospital admission for an asthma exacerbation. Patient characteristics and frequencies of RV in nasal specimens were analyzed, by reverse-transcription polymerase chain reaction (RT-PCR), at asthma-related hospital admission and at a 3-month convalescent follow-up visit. Results. RV was detected by RT-PCR in 21% of hospitalized patients over a 4-year period and in 1.3% of patients who returned for a 3-month follow-up visit. RV detection was strongly associated with hospitalization for asthma (adjusted odds ratio [OR], 15.1 [95% confidence interval {CI}, 1.88-121.4]). After adjustment for baseline asthma severity, RV-positive patients were more likely than RV-negative patients to be current smokers and nonusers of inhaled corticosteroids (ICSs) (adjusted OR, 11.18 [95% CI, 2.37-52.81]; P = .002). Conclusions. RV respiratory infection is an etiologic agent in severe asthma exacerbations necessitating hospitalization in adults. Compared with hospitalized patients with asthma who were RV negative, RV-positive patients were significantly more likely to be smokers and nonusers of ICSs.
UR - http://www.scopus.com/inward/record.url?scp=33646901002&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646901002&partnerID=8YFLogxK
U2 - 10.1086/503809
DO - 10.1086/503809
M3 - Article
C2 - 16652282
AN - SCOPUS:33646901002
SN - 0022-1899
VL - 193
SP - 1536
EP - 1543
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -