The relationship of resting cerebral blood flow and brain activation during a social cognition task in adolescents with chronic moderate to severe traumatic brain injury

A preliminary investigation

Mary R. Newsome, Randall S. Scheibel, Zili Chu, Jill V. Hunter, Xiaoqi Li, Elisabeth A. Wilde, Hanzhang Lu, Zhiyue J. Wang, Xiaodi Lin, Joel L. Steinberg, Ana C. Vasquez, Lori Cook, Harvey S. Levin

Research output: Contribution to journalArticle

Abstract

Alterations in cerebrovascular function are evident acutely in moderate to severe traumatic brain injury (TBI), although less is known about their chronic effects. Adolescent and adult patients with moderate to severe TBI have been reported to demonstrate diffuse activation throughout the brain during functional magnetic resonance imaging (fMRI). Because fMRI is a measure related to blood flow, it is possible that any deficits in blood flow may alter activation. An arterial spin labeling (ASL) perfusion sequence was performed on seven adolescents with chronic moderate to severe TBI and seven typically developing (TD) adolescents during the same session in which they had performed a social cognition task during fMRI. In the TD group, prefrontal CBF was positively related to prefrontal activation and negatively related to non-prefrontal, posterior, brain activation. This relationship was not seen in the TBI group, who demonstrated a greater positive relationship between prefrontal CBF and non-prefrontal activation than the TD group. An analysis of CBF data independent of fMRI showed reduced CBF in the right non-prefrontal region (p

Original languageEnglish (US)
Pages (from-to)255-266
Number of pages12
JournalInternational Journal of Developmental Neuroscience
Volume30
Issue number3
DOIs
StatePublished - May 2012
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Cognition
Magnetic Resonance Imaging
Brain
Perfusion
Traumatic Brain Injury

Keywords

  • Adolescents
  • Cerebral blood flow
  • FMRI
  • Social cognition
  • Traumatic brain injury

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

The relationship of resting cerebral blood flow and brain activation during a social cognition task in adolescents with chronic moderate to severe traumatic brain injury : A preliminary investigation. / Newsome, Mary R.; Scheibel, Randall S.; Chu, Zili; Hunter, Jill V.; Li, Xiaoqi; Wilde, Elisabeth A.; Lu, Hanzhang; Wang, Zhiyue J.; Lin, Xiaodi; Steinberg, Joel L.; Vasquez, Ana C.; Cook, Lori; Levin, Harvey S.

In: International Journal of Developmental Neuroscience, Vol. 30, No. 3, 05.2012, p. 255-266.

Research output: Contribution to journalArticle

Newsome, Mary R. ; Scheibel, Randall S. ; Chu, Zili ; Hunter, Jill V. ; Li, Xiaoqi ; Wilde, Elisabeth A. ; Lu, Hanzhang ; Wang, Zhiyue J. ; Lin, Xiaodi ; Steinberg, Joel L. ; Vasquez, Ana C. ; Cook, Lori ; Levin, Harvey S. / The relationship of resting cerebral blood flow and brain activation during a social cognition task in adolescents with chronic moderate to severe traumatic brain injury : A preliminary investigation. In: International Journal of Developmental Neuroscience. 2012 ; Vol. 30, No. 3. pp. 255-266.
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