The relationship of obesity to ischemic outcomes following coronary stent placement in contemporary practice

Jack L. Martin, Gang Jia, Seth Martin, Timothy A. Shapiro, Howard C. Herrmann, Peter M. DiBattiste, Eric J. Topol, David J. Moliterno

Research output: Contribution to journalArticle

Abstract

Objectives: We analyzed the relationship of obesity, determined by body mass index (BMI), to short- and long-term outcomes in the TARGET trial. BACKGROUND: Previous studies have conflicting findings regarding the relationship of BMI to outcomes following percutaneous coronary intervention (PCI). Methods: The TARGET trial studied the use of glycoprotein (GP) IIb/IIIa inhibition in patients undergoing planned coronary stent placement. Results: Eighty-one percent of all patients were overweight (BMI > 25), 36% were obese (BMI > 30), and United States patients were more frequently obese (38.7% vs. 25.8%, P <0.001). Obese patients had a similar 30-day ischemic event rate compared with nonobese patients, but less major bleeding (0.4% vs. 1.1%, P = 0.013). Six-month death and myocardial infarction rates were similar in obese and nonobese patients. There was a J-shaped relationship between 6-month target vessel revascularization (TVR) and BMI with the lowest incidence of TVR at BMI 27.5. Six-month TVR was higher in the morbidly (BMI > 35) obese (12.4% vs 8.7%, P <0.05). In extremely (BMI > 32) obese patients, this relationship was more significant (TVR 11.3% vs. 8.5%, P = 0.007), particularly in patients

Original languageEnglish (US)
Pages (from-to)563-570
Number of pages8
JournalCatheterization and Cardiovascular Interventions
Volume67
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Stents
Obesity
Body Mass Index
Platelet Glycoprotein GPIIb-IIIa Complex
Percutaneous Coronary Intervention

Keywords

  • Body mass index
  • Coronary artery disease
  • Glycoprotein IIb/IIIa inhibition
  • Percutaneous coronary intervention
  • Target vessel revascularization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

The relationship of obesity to ischemic outcomes following coronary stent placement in contemporary practice. / Martin, Jack L.; Jia, Gang; Martin, Seth; Shapiro, Timothy A.; Herrmann, Howard C.; DiBattiste, Peter M.; Topol, Eric J.; Moliterno, David J.

In: Catheterization and Cardiovascular Interventions, Vol. 67, No. 4, 04.2006, p. 563-570.

Research output: Contribution to journalArticle

Martin, Jack L. ; Jia, Gang ; Martin, Seth ; Shapiro, Timothy A. ; Herrmann, Howard C. ; DiBattiste, Peter M. ; Topol, Eric J. ; Moliterno, David J. / The relationship of obesity to ischemic outcomes following coronary stent placement in contemporary practice. In: Catheterization and Cardiovascular Interventions. 2006 ; Vol. 67, No. 4. pp. 563-570.
@article{d248ceaf387e4c0a88b1c4e8dfece63c,
title = "The relationship of obesity to ischemic outcomes following coronary stent placement in contemporary practice",
abstract = "Objectives: We analyzed the relationship of obesity, determined by body mass index (BMI), to short- and long-term outcomes in the TARGET trial. BACKGROUND: Previous studies have conflicting findings regarding the relationship of BMI to outcomes following percutaneous coronary intervention (PCI). Methods: The TARGET trial studied the use of glycoprotein (GP) IIb/IIIa inhibition in patients undergoing planned coronary stent placement. Results: Eighty-one percent of all patients were overweight (BMI > 25), 36{\%} were obese (BMI > 30), and United States patients were more frequently obese (38.7{\%} vs. 25.8{\%}, P <0.001). Obese patients had a similar 30-day ischemic event rate compared with nonobese patients, but less major bleeding (0.4{\%} vs. 1.1{\%}, P = 0.013). Six-month death and myocardial infarction rates were similar in obese and nonobese patients. There was a J-shaped relationship between 6-month target vessel revascularization (TVR) and BMI with the lowest incidence of TVR at BMI 27.5. Six-month TVR was higher in the morbidly (BMI > 35) obese (12.4{\%} vs 8.7{\%}, P <0.05). In extremely (BMI > 32) obese patients, this relationship was more significant (TVR 11.3{\%} vs. 8.5{\%}, P = 0.007), particularly in patients",
keywords = "Body mass index, Coronary artery disease, Glycoprotein IIb/IIIa inhibition, Percutaneous coronary intervention, Target vessel revascularization",
author = "Martin, {Jack L.} and Gang Jia and Seth Martin and Shapiro, {Timothy A.} and Herrmann, {Howard C.} and DiBattiste, {Peter M.} and Topol, {Eric J.} and Moliterno, {David J.}",
year = "2006",
month = "4",
doi = "10.1002/ccd.20622",
language = "English (US)",
volume = "67",
pages = "563--570",
journal = "Catheterization and Cardiovascular Interventions",
issn = "1522-1946",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - The relationship of obesity to ischemic outcomes following coronary stent placement in contemporary practice

AU - Martin, Jack L.

AU - Jia, Gang

AU - Martin, Seth

AU - Shapiro, Timothy A.

AU - Herrmann, Howard C.

AU - DiBattiste, Peter M.

AU - Topol, Eric J.

AU - Moliterno, David J.

PY - 2006/4

Y1 - 2006/4

N2 - Objectives: We analyzed the relationship of obesity, determined by body mass index (BMI), to short- and long-term outcomes in the TARGET trial. BACKGROUND: Previous studies have conflicting findings regarding the relationship of BMI to outcomes following percutaneous coronary intervention (PCI). Methods: The TARGET trial studied the use of glycoprotein (GP) IIb/IIIa inhibition in patients undergoing planned coronary stent placement. Results: Eighty-one percent of all patients were overweight (BMI > 25), 36% were obese (BMI > 30), and United States patients were more frequently obese (38.7% vs. 25.8%, P <0.001). Obese patients had a similar 30-day ischemic event rate compared with nonobese patients, but less major bleeding (0.4% vs. 1.1%, P = 0.013). Six-month death and myocardial infarction rates were similar in obese and nonobese patients. There was a J-shaped relationship between 6-month target vessel revascularization (TVR) and BMI with the lowest incidence of TVR at BMI 27.5. Six-month TVR was higher in the morbidly (BMI > 35) obese (12.4% vs 8.7%, P <0.05). In extremely (BMI > 32) obese patients, this relationship was more significant (TVR 11.3% vs. 8.5%, P = 0.007), particularly in patients

AB - Objectives: We analyzed the relationship of obesity, determined by body mass index (BMI), to short- and long-term outcomes in the TARGET trial. BACKGROUND: Previous studies have conflicting findings regarding the relationship of BMI to outcomes following percutaneous coronary intervention (PCI). Methods: The TARGET trial studied the use of glycoprotein (GP) IIb/IIIa inhibition in patients undergoing planned coronary stent placement. Results: Eighty-one percent of all patients were overweight (BMI > 25), 36% were obese (BMI > 30), and United States patients were more frequently obese (38.7% vs. 25.8%, P <0.001). Obese patients had a similar 30-day ischemic event rate compared with nonobese patients, but less major bleeding (0.4% vs. 1.1%, P = 0.013). Six-month death and myocardial infarction rates were similar in obese and nonobese patients. There was a J-shaped relationship between 6-month target vessel revascularization (TVR) and BMI with the lowest incidence of TVR at BMI 27.5. Six-month TVR was higher in the morbidly (BMI > 35) obese (12.4% vs 8.7%, P <0.05). In extremely (BMI > 32) obese patients, this relationship was more significant (TVR 11.3% vs. 8.5%, P = 0.007), particularly in patients

KW - Body mass index

KW - Coronary artery disease

KW - Glycoprotein IIb/IIIa inhibition

KW - Percutaneous coronary intervention

KW - Target vessel revascularization

UR - http://www.scopus.com/inward/record.url?scp=33646067441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646067441&partnerID=8YFLogxK

U2 - 10.1002/ccd.20622

DO - 10.1002/ccd.20622

M3 - Article

C2 - 16532491

AN - SCOPUS:33646067441

VL - 67

SP - 563

EP - 570

JO - Catheterization and Cardiovascular Interventions

JF - Catheterization and Cardiovascular Interventions

SN - 1522-1946

IS - 4

ER -