TY - JOUR
T1 - The relationship of lean body mass with aging to the development of diabetes
AU - Kalyani, Rita R.
AU - Metter, E. Jeffrey
AU - Xue, Qian Li
AU - Egan, Josephine M.
AU - Chia, Chee W.
AU - Studenski, Stephanie
AU - Shaffer, Nancy Chiles
AU - Golden, Sherita
AU - Al-Sofiani, Mohammed
AU - Florez, Hermes
AU - Ferrucci, Luigi
N1 - Funding Information:
This study was supported by the NIH/NIDDK (R03 DK109163) and the intramural research program of the National Institute on Aging.
Publisher Copyright:
© Published by Oxford University Press on behalf of the Endocrine Society 2020. This work is written by (a) US Government employee(s) and is in the public domain in the US. This Open Access article contains public sector information licensed under the Open Government Licence v2.0 (http://www.nationalarchives.gov.uk/doc/open-government-licence/version/2/).
PY - 2020
Y1 - 2020
N2 - Context: Older adults have the greatest burden of diabetes; however, the contribution of age-related muscle loss to its development remains unclear. Objective: We assessed the relationship of lean body mass with aging to incident diabetes in community-dwelling adults. Design and Setting: We studied participants in the Baltimore Longitudinal Study of Aging with median follow-up of 7 years (range 1-16). Cox proportional hazard models with age as the time scale were used. Time-dependent lean body mass measures were updated at each follow-up visit available. Participants: Participants included 871 men and 984 women without diabetes who had ≥ 1 assessment of body composition using dual x-ray absorptiometry. Main Outcomes: Incident diabetes, defined as self-reported history and use of glucose-lowering medications; or fasting plasma glucose ≥ 126 mg/dL and 2-hour oral glucose tolerance test glucose ≥ 200 mg/dL either at the same visit or 2 consecutive visits. Results: The baseline mean [standard deviation] age was 58.9 [17.3] years. Men and women with a higher percentage of total lean body mass had lower fasting and 2-hour glucose levels, and less prediabetes (all P < 0.01). Among men, comparing highest versus lowest quartiles, percentage of total lean body mass (hazard ratio [HR], 0.46; 95% confidence interval, 0.22-0.97), percentage leg lean mass (HR, 0.38; 0.15-0.96), and lean-to-fat mass ratio (HR, 0.39; 0.17-0.89) were inversely associated with incident diabetes after accounting for race and attenuated after adjustment for height and weight. Conversely, absolute total lean body mass was positively associated with incident diabetes among women, with similar trends in men. No associations were observed with muscle strength or quality. Conclusions: Relatively lower lean body mass with aging is associated with incident diabetes in men and partially related to anthropometrics, but not so in women.
AB - Context: Older adults have the greatest burden of diabetes; however, the contribution of age-related muscle loss to its development remains unclear. Objective: We assessed the relationship of lean body mass with aging to incident diabetes in community-dwelling adults. Design and Setting: We studied participants in the Baltimore Longitudinal Study of Aging with median follow-up of 7 years (range 1-16). Cox proportional hazard models with age as the time scale were used. Time-dependent lean body mass measures were updated at each follow-up visit available. Participants: Participants included 871 men and 984 women without diabetes who had ≥ 1 assessment of body composition using dual x-ray absorptiometry. Main Outcomes: Incident diabetes, defined as self-reported history and use of glucose-lowering medications; or fasting plasma glucose ≥ 126 mg/dL and 2-hour oral glucose tolerance test glucose ≥ 200 mg/dL either at the same visit or 2 consecutive visits. Results: The baseline mean [standard deviation] age was 58.9 [17.3] years. Men and women with a higher percentage of total lean body mass had lower fasting and 2-hour glucose levels, and less prediabetes (all P < 0.01). Among men, comparing highest versus lowest quartiles, percentage of total lean body mass (hazard ratio [HR], 0.46; 95% confidence interval, 0.22-0.97), percentage leg lean mass (HR, 0.38; 0.15-0.96), and lean-to-fat mass ratio (HR, 0.39; 0.17-0.89) were inversely associated with incident diabetes after accounting for race and attenuated after adjustment for height and weight. Conversely, absolute total lean body mass was positively associated with incident diabetes among women, with similar trends in men. No associations were observed with muscle strength or quality. Conclusions: Relatively lower lean body mass with aging is associated with incident diabetes in men and partially related to anthropometrics, but not so in women.
KW - Aging
KW - Body composition
KW - Diabetes
KW - Lean body mass
KW - Muscle
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U2 - 10.1210/JENDSO/BVAA043
DO - 10.1210/JENDSO/BVAA043
M3 - Article
AN - SCOPUS:85096396750
SN - 2472-1972
VL - 4
SP - 1
EP - 16
JO - Journal of the Endocrine Society
JF - Journal of the Endocrine Society
IS - 7
ER -