TY - JOUR
T1 - The relationship of blood lead to blood pressure in a longitudinal study of working men
AU - Weiss, S. T.
AU - Muñoz, A.
AU - Stein, A.
AU - Sparrow, D.
AU - Speizer, F. E.
PY - 1986/5
Y1 - 1986/5
N2 - The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.
AB - The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.
KW - Blood pressure
KW - Hypertension
KW - Lead
KW - Longitudinal studies
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U2 - 10.1093/oxfordjournals.aje.a114309
DO - 10.1093/oxfordjournals.aje.a114309
M3 - Article
C2 - 3485920
AN - SCOPUS:0022452677
VL - 123
SP - 800
EP - 808
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 5
ER -