The relationship of blood lead to blood pressure in a longitudinal study of working men

S. T. Weiss, A. Muñoz, A. Stein, D. Sparrow, F. E. Speizer

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.

Original languageEnglish (US)
Pages (from-to)800-808
Number of pages9
JournalAmerican journal of epidemiology
Volume123
Issue number5
DOIs
StatePublished - May 1986
Externally publishedYes

Keywords

  • Blood pressure
  • Hypertension
  • Lead
  • Longitudinal studies

ASJC Scopus subject areas

  • Epidemiology

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