The relationship of blood lead to blood pressure in a longitudinal study of working men

S. T. Weiss; A. Muñoz; A. Stein; D. Sparrow; F. E. Speizer

doi:10.1093/oxfordjournals.aje.a114309

The relationship of blood lead to blood pressure in a longitudinal study of working men

S. T. Weiss, A. Muñoz, A. Stein, D. Sparrow, F. E. Speizer

Research output: Contribution to journal › Article › peer-review

Abstract

The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.

Original language	English (US)
Pages (from-to)	800-808
Number of pages	9
Journal	American journal of epidemiology
Volume	123
Issue number	5
DOIs	https://doi.org/10.1093/oxfordjournals.aje.a114309
State	Published - May 1986
Externally published	Yes

Keywords

Blood pressure
Hypertension
Lead
Longitudinal studies

ASJC Scopus subject areas

Epidemiology

Access to Document

10.1093/oxfordjournals.aje.a114309

Cite this

@article{303785521276455e9be9ba4859070cb0,

title = "The relationship of blood lead to blood pressure in a longitudinal study of working men",

abstract = "The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.",

keywords = "Blood pressure, Hypertension, Lead, Longitudinal studies",

author = "Weiss, {S. T.} and A. Mu{\~n}oz and A. Stein and D. Sparrow and Speizer, {F. E.}",

note = "Funding Information: This work was supported in part by Clinical Investigator Award No. 00740 and Grant No. HL19170 from the Division of Lung Disease, National Heart, Lung and Blood Institute (Dr. Weiss).",

year = "1986",

month = may,

doi = "10.1093/oxfordjournals.aje.a114309",

language = "English (US)",

volume = "123",

pages = "800--808",

journal = "American Journal of Epidemiology",

issn = "0002-9262",

publisher = "Oxford University Press",

number = "5",

}

TY - JOUR

T1 - The relationship of blood lead to blood pressure in a longitudinal study of working men

AU - Weiss, S. T.

AU - Muñoz, A.

AU - Stein, A.

AU - Sparrow, D.

AU - Speizer, F. E.

N1 - Funding Information: This work was supported in part by Clinical Investigator Award No. 00740 and Grant No. HL19170 from the Division of Lung Disease, National Heart, Lung and Blood Institute (Dr. Weiss).

PY - 1986/5

Y1 - 1986/5

N2 - The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.

AB - The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.

KW - Blood pressure

KW - Hypertension

KW - Lead

KW - Longitudinal studies

UR - http://www.scopus.com/inward/record.url?scp=0022452677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022452677&partnerID=8YFLogxK

U2 - 10.1093/oxfordjournals.aje.a114309

DO - 10.1093/oxfordjournals.aje.a114309

M3 - Article

C2 - 3485920

AN - SCOPUS:0022452677

VL - 123

SP - 800

EP - 808

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 5

ER -

The relationship of blood lead to blood pressure in a longitudinal study of working men

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this