The relationship of asthma-specific quality of life during pregnancy to subsequent asthma and perinatal morbidity

Michael Schatz, Mitchell P. Dombrowski, Robert A Wise, Yinglei Lai, Mark Landon, Roger B. Newman, Dwight J. Rouse, Menachem Miodovnik, Mary Jo O'Sullivan, Steve N. Caritis, Kenneth J. Leveno, Ronald J. Wapner, Deborah L. Conway

Research output: Contribution to journalArticle

Abstract

Objective. To determine whether asthma-specific quality of life during pregnancy is related to asthma exacerbations and to perinatal outcomes. Methods. This was a secondary analysis of data from a randomized controlled trial of inhaled beclomethasone versus theophylline in the treatment of moderate asthma during pregnancy. The Juniper Asthma Quality of Life Questionnaire (AQLQ) was administered to patients at enrollment. Exacerbations were defined as asthma symptoms requiring a hospitalization, unscheduled medical visit, or oral corticosteroid course. Results. Quality of life assessments were provided by 310 of the 385 participants who completed the study. There was more than a 25% decrease in the odds of a subsequent asthma exacerbation for every 1-point increase in AQLQ score for the overall score (odds ratio OR 0.73, 95% confidence interval CI 0.55-0.96), emotion domain (OR 0.72, 95% CI 0.59-0.88), and symptoms domain (OR 0.73, 95% CI 0.57-0.94). These relationships were not significantly influenced by initial symptom frequency or forced expiratory volume in 1 s (FEV1). No significant relationships were demonstrated between enrollment AQLQ scores and preeclampsia, preterm birth, low birth weight, or small for gestational age. Conclusion. Asthma-specific quality of life in early pregnancy is related to subsequent asthma morbidity during pregnancy but not to perinatal outcomes.

Original languageEnglish (US)
Pages (from-to)46-50
Number of pages5
JournalJournal of Asthma
Volume47
Issue number1
DOIs
StatePublished - 2010

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Asthma
Quality of Life
Morbidity
Pregnancy
Juniperus
Beclomethasone
Premature Birth
Forced Expiratory Volume
Low Birth Weight Infant
Theophylline
Pre-Eclampsia
Gestational Age
Adrenal Cortex Hormones
Emotions
Hospitalization
Randomized Controlled Trials
Odds Ratio
Confidence Intervals
Surveys and Questionnaires

Keywords

  • Asthma
  • Exacerbations
  • Perinatal outcomes
  • Pulmonary function
  • Quality of life

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health

Cite this

The relationship of asthma-specific quality of life during pregnancy to subsequent asthma and perinatal morbidity. / Schatz, Michael; Dombrowski, Mitchell P.; Wise, Robert A; Lai, Yinglei; Landon, Mark; Newman, Roger B.; Rouse, Dwight J.; Miodovnik, Menachem; O'Sullivan, Mary Jo; Caritis, Steve N.; Leveno, Kenneth J.; Wapner, Ronald J.; Conway, Deborah L.

In: Journal of Asthma, Vol. 47, No. 1, 2010, p. 46-50.

Research output: Contribution to journalArticle

Schatz, M, Dombrowski, MP, Wise, RA, Lai, Y, Landon, M, Newman, RB, Rouse, DJ, Miodovnik, M, O'Sullivan, MJ, Caritis, SN, Leveno, KJ, Wapner, RJ & Conway, DL 2010, 'The relationship of asthma-specific quality of life during pregnancy to subsequent asthma and perinatal morbidity', Journal of Asthma, vol. 47, no. 1, pp. 46-50. https://doi.org/10.3109/02770900903483758
Schatz, Michael ; Dombrowski, Mitchell P. ; Wise, Robert A ; Lai, Yinglei ; Landon, Mark ; Newman, Roger B. ; Rouse, Dwight J. ; Miodovnik, Menachem ; O'Sullivan, Mary Jo ; Caritis, Steve N. ; Leveno, Kenneth J. ; Wapner, Ronald J. ; Conway, Deborah L. / The relationship of asthma-specific quality of life during pregnancy to subsequent asthma and perinatal morbidity. In: Journal of Asthma. 2010 ; Vol. 47, No. 1. pp. 46-50.
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