The relationship in neonates between clinically measured head circumference and brain volume estimated from head CT-scans

Anna A. Lindley, Jane E. Benson, Cara Grimes, Theodore M. Cole, Allen A. Herman

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To determine if the frontal-occipital head circumference correlates with brain volume on CT and to investigate correlations between the volumes of different brain subdivisions in live neonates.Methods: Records were studied from 27 neonates with anatomically normal head CT-scans which were ordered for clinical reasons, and which were performed at Johns Hopkins Hospital. Clinical data were abstracted from medical records. Brain volumes were estimated by digitizing the structures of interest on each slice of head CT-scans.Results: In this sample of 27 infants with a mean birth weight of 3000.4±668 g, mean head circumference of 33.5±1.8 cm, and mean gestational age of 37 weeks and 4 days±24 days, the mean of total brain volume was 333.0±78.3 ml. The correlation between clinically measured head circumference and total brain volume was 0.55 (P

Original languageEnglish (US)
Pages (from-to)17-29
Number of pages13
JournalEarly Human Development
Volume56
Issue number1
DOIs
StatePublished - Sep 1999

Keywords

  • CT-scan
  • Head circumference
  • Human infant brain
  • Volumetric measurement

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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