TY - JOUR
T1 - The Relationship between Urine Uromodulin and Blood Pressure Changes
T2 - The DASH-Sodium Trial
AU - Bakhoum, Christine Y.
AU - Anderson, Cheryl A.M.
AU - Juraschek, Stephen P.
AU - Rebholz, Casey M.
AU - Appel, Lawrence J.
AU - Miller, Edgar R.
AU - Parikh, Chirag R.
AU - Obeid, Wassim
AU - Rifkin, Dena E.
AU - Ix, Joachim H.
AU - Garimella, Pranav S.
N1 - Publisher Copyright:
© 2020 American Journal of Hypertension, Ltd 2020. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
PY - 2021/2/1
Y1 - 2021/2/1
N2 - BACKGROUND: Uromodulin modulates the sodium-potassium-two-chloride transporter in the thick ascending limb of the loop of Henle, and its overexpression in murine models leads to salt-induced hypertension. We hypothesized that individuals with higher baseline levels of urine uromodulin would have a greater increase in systolic blood pressure (SBP) for the same increase in sodium compared with those with lower uromodulin levels. METHODS: We used data from 157 subjects randomized to the control diet of the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial who were assigned to 30 days of low (1,500 mg/d), medium (2,400 mg/d), and high salt (3,300 mg/d) diets in random order. Blood pressure was measured prerandomization and then weekly during each feeding period. We evaluated the association of prerandomization urine uromodulin with change in SBP between diets, as measured at the end of each feeding period, using multivariable linear regression. RESULTS: Baseline urine uromodulin stratified by tertiles was ≤17.64, 17.65-31.97, and ≥31.98 μg/ml. Across the tertiles, there were no significant differences in SBP at baseline, nor was there a differential effect of sodium diet on SBP across tertiles (low to high, P = 0.81). After adjusting for age, sex, body mass index, and race, uromodulin levels were not significantly associated with SBP change from low to high sodium diet (P = 0.42). CONCLUSIONS: In a randomized trial of different levels of salt intake, higher urine uromodulin levels were not associated with a greater increase in blood pressure in response to high salt intake.
AB - BACKGROUND: Uromodulin modulates the sodium-potassium-two-chloride transporter in the thick ascending limb of the loop of Henle, and its overexpression in murine models leads to salt-induced hypertension. We hypothesized that individuals with higher baseline levels of urine uromodulin would have a greater increase in systolic blood pressure (SBP) for the same increase in sodium compared with those with lower uromodulin levels. METHODS: We used data from 157 subjects randomized to the control diet of the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial who were assigned to 30 days of low (1,500 mg/d), medium (2,400 mg/d), and high salt (3,300 mg/d) diets in random order. Blood pressure was measured prerandomization and then weekly during each feeding period. We evaluated the association of prerandomization urine uromodulin with change in SBP between diets, as measured at the end of each feeding period, using multivariable linear regression. RESULTS: Baseline urine uromodulin stratified by tertiles was ≤17.64, 17.65-31.97, and ≥31.98 μg/ml. Across the tertiles, there were no significant differences in SBP at baseline, nor was there a differential effect of sodium diet on SBP across tertiles (low to high, P = 0.81). After adjusting for age, sex, body mass index, and race, uromodulin levels were not significantly associated with SBP change from low to high sodium diet (P = 0.42). CONCLUSIONS: In a randomized trial of different levels of salt intake, higher urine uromodulin levels were not associated with a greater increase in blood pressure in response to high salt intake.
KW - DASH
KW - blood pressure
KW - hypertension
KW - salt sensitivity
KW - sodium
KW - uromodulin
UR - http://www.scopus.com/inward/record.url?scp=85102909358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85102909358&partnerID=8YFLogxK
U2 - 10.1093/ajh/hpaa140
DO - 10.1093/ajh/hpaa140
M3 - Article
C2 - 32856709
AN - SCOPUS:85102909358
SN - 0895-7061
VL - 34
SP - 154
EP - 156
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 2
ER -