Abstract
Objective: We investigated the effects of chronic exposures to particulate and traffic-related air pollution on allostatic load (AL) score, a marker of cumulative biological risk, among youth with type 1 diabetes. Research design and methods: Participants were drawn from five clinical sites of the SEARCH for Diabetes in Youth (SEARCH) study (n = 2338). Baseline questionnaires, anthropometric measures, and a fasting blood test were taken at a clinic visit between 2001 and 2005. AL was operationalized using 10 biomarkers reflecting cardiovascular, metabolic, and inflammatory risk. Annual residential exposures to PM2.5 and proximity to heavily-trafficked major roadways were estimated for each participant. Poisson regression models adjusted for sociodemographic and lifestyle factors were conducted for each exposure. Results: No significant associations were observed between exposures to PM2.5 or proximity to traffic and AL score, however analyses were suggestive of effect modification by race for residential distance to heavily-trafficked major roadways (p = 0.02). In stratified analyses, residing <100, 100-<200 and 200-<400 m compared to 400 m or more from heavily-trafficked major roadways was associated with 11%, 26% and 14% increases in AL score, respectively (95% CIs: -4, 29; 9, 45; −1, 30) for non-white participants compared to 6%, −2%, and −2% changes (95% CIs: -2, 15; −10, 7; −8, 6) for white participants. Conclusions: Among this population of youth with type 1 diabetes, we did not observe consistent relationships between chronic exposures to particulate and traffic-related air pollution and changes in AL score, however associations for traffic-related pollution exposures may differ by race/ethnicity and warrant further examination.
Original language | English (US) |
---|---|
Article number | 111075 |
Journal | Environmental research |
Volume | 197 |
DOIs | |
State | Published - Jun 2021 |
Keywords
- Air pollution
- Allostatic load
- Chronic exposure
- Type 1 diabetes
ASJC Scopus subject areas
- Biochemistry
- Environmental Science(all)
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The relationship between traffic-related air pollution exposures and allostatic load score among youth with type 1 diabetes in the SEARCH cohort. / Montresor-López, Jessica A.; Reading, Stephanie R.; Yanosky, Jeffrey D. et al.
In: Environmental research, Vol. 197, 111075, 06.2021.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - The relationship between traffic-related air pollution exposures and allostatic load score among youth with type 1 diabetes in the SEARCH cohort
AU - Montresor-López, Jessica A.
AU - Reading, Stephanie R.
AU - Yanosky, Jeffrey D.
AU - Mittleman, Murray A.
AU - Bell, Ronny A.
AU - Crume, Tessa L.
AU - Dabelea, Dana
AU - Dolan, Lawrence
AU - D'Agostino, Ralph B.
AU - Marcovina, Santica M.
AU - Pihoker, Catherine
AU - Reynolds, Kristi
AU - Urbina, Elaine
AU - Liese, Angela D.
AU - Quirós-Alcalá, Lesliam
AU - Smith, J. Carson
AU - Bueno de Mesquita, P. Jacob
AU - Puett, Robin C.
N1 - Funding Information: Funding for the SEARCH Air Ancillary Study is from the National Institutes of Health , National Institute of Environmental Health Sciences (grant number R01 ES019168 ). The SEARCH for Diabetes in Youth Study is funded by the Centers for Disease Control and Prevention (PA numbers 00097 , DP-05-069 , and DP-10-001 ) and additionally supported by the National Institute of Diabetes and Digestive and Kidney Diseases . Support was also provided by the South Carolina Clinical & Translational Research Institute at the Medical University of South Carolina (NIH/ National Center for Advancing Translational Sciences ( NCATS ) grant number UL1 TR000062 ); Seattle Children’s Hospital and the University of Washington (NIH/ NCATS grant number UL1 TR00423 ); University of Colorado Pediatric Clinical and Translational Research Center (NIH/ NCATS grant Number UL1 TR000154 ); the Barbara Davis Center at the University of Colorado Denver (DERC NIH grant number P30 DK57516 ); the University of Cincinnati (NIH/NCATS grant number UL1 TR000077 ); and the Children with Medical Handicaps program managed by the Ohio Department of Health . The sponsors had no involvement in study design; in data collection, analysis and interpretation; in writing of the manuscript; and in the decision to submit the article for publication. Funding Information: Funding for the SEARCH Air Ancillary Study is from the National Institutes of Health, National Institute of Environmental Health Sciences grant R01 ES019168. The SEARCH for Diabetes in Youth Study is funded by the Centers for Disease Control and Prevention (PA numbers 00097, DP-05-069, and DP-10-001) and additionally supported by the National Institute of Diabetes and Digestive and Kidney Diseases. Support was also provided by the South Carolina Clinical & Translational Research Institute at the Medical University of South Carolina, NIH/National Center for Advancing Translational Sciences (NCATS) grant number UL1 TR000062; Seattle Children's Hospital and the University of Washington, NIH/NCATS grant number UL1 TR00423; University of Colorado Pediatric Clinical and Translational Research Center, NIH/NCATS grant Number UL1 TR000154; the Barbara Davis Center at the University of Colorado at Denver (DERC NIH grant number P30 DK57516); the University of Cincinnati, NIH/NCATS grant number UL1 TR000077; and the Children with Medical Handicaps program managed by the Ohio Department of Health. The sponsors had no involvement in study design; in data collection, analysis and interpretation; in writing of the manuscript; and in the decision to submit the article for publication.The authors graciously thank everyone involved with the SEARCH for Diabetes in Youth study ? including participants and their families, as well as health care providers ? without whom this study would not have been possible. The authors also thank James Hibbert, University of South Carolina, for geocoding addresses, and Verada Shevade, University of Maryland, for assisting with formatting. Funding for the SEARCH Air Ancillary Study is from the National Institutes of Health, National Institute of Environmental Health Sciences (grant number R01 ES019168). The SEARCH for Diabetes in Youth Study is funded by the Centers for Disease Control and Prevention (PA numbers 00097, DP-05-069, and DP-10-001) and additionally supported by the National Institute of Diabetes and Digestive and Kidney Diseases. Support was also provided by the South Carolina Clinical & Translational Research Institute at the Medical University of South Carolina (NIH/National Center for Advancing Translational Sciences (NCATS) grant number UL1 TR000062); Seattle Children's Hospital and the University of Washington (NIH/NCATS grant number UL1 TR00423); University of Colorado Pediatric Clinical and Translational Research Center (NIH/NCATS grant Number UL1 TR000154); the Barbara Davis Center at the University of Colorado Denver (DERC NIH grant number P30 DK57516); the University of Cincinnati (NIH/NCATS grant number UL1 TR000077); and the Children with Medical Handicaps program managed by the Ohio Department of Health. The sponsors had no involvement in study design; in data collection, analysis and interpretation; in writing of the manuscript; and in the decision to submit the article for publication. Contract numbers for SEARCH sites include: Kaiser Permanente Southern California (U18DP006133, U48/CCU919219, U01 DP000246, and U18DP002714), University of Colorado Denver (U18DP006139, U48/CCU819241-3, U01 DP000247, and U18DP000247-06A1), Children's Hospital Medical Center (Cincinnati) (U18DP006134, U48/CCU519239, U01 DP000248, and 1U18DP002709), University of North Carolina at Chapel Hill (U18DP006138, U48/CCU419249, U01 DP000254, and U18DP002708), Seattle Children's Hospital (U18DP006136, U58/CCU019235-4, U01 DP000244, and U18DP002710-01), Wake Forest University School of Medicine (U18DP006131, U48/CCU919219, U01 DP000250, and 200-2010-35171). The SEARCH writing group for this manuscript included J.M. (vice chair), S.R. J.Y. R.B. T.C. L.D. R.D. C.P. K.R. A.L. and R.P (chair). J.M. developed the concept for the manuscript, analyzed data, and wrote the manuscript. S.R. and K.R. contributed to the development of the AL index and reviewed/edited the manuscript. J.Y. developed the exposure models, contributed to the methods, and reviewed/edited the manuscript. M.M. provided epidemiological expertise and reviewed/edited the manuscript. R.D. provided statistical expertise and assisted with analysis. R.B. T.C. D.D, L.D, S.M. C.P. P.J.B. and J.S. reviewed/edited the manuscript. E.U. provided medical expertise related to the biomarkers in the AL score and reviewed/edited the manuscript. A.L. contributed to the development of the manuscript and reviewed/edited. L.Q. assisted with analysis and reviewed/edited the manuscript. R.P. assisted with the development of the manuscript, contributed to the analysis and discussion, and reviewed/edited. The guarantors are J.M. and R.P. The authors declare no relevant conflicts of interest. Funding Information: Funding for the SEARCH Air Ancillary Study is from the National Institutes of Health , National Institute of Environmental Health Sciences grant R01 ES019168 . The SEARCH for Diabetes in Youth Study is funded by the Centers for Disease Control and Prevention (PA numbers 00097 , DP-05-069 , and DP-10-001 ) and additionally supported by the National Institute of Diabetes and Digestive and Kidney Diseases . Support was also provided by the South Carolina Clinical & Translational Research Institute at the Medical University of South Carolina , NIH / National Center for Advancing Translational Sciences ( NCATS ) grant number UL1 TR000062 ; Seattle Children’s Hospital and the University of Washington , NIH / NCATS grant number UL1 TR00423 ; University of Colorado Pediatric Clinical and Translational Research Center , NIH / NCATS grant Number UL1 TR000154 ; the Barbara Davis Center at the University of Colorado at Denver (DERC NIH grant number P30 DK57516 ); the University of Cincinnati , NIH / NCATS grant number UL1 TR000077 ; and the Children with Medical Handicaps program managed by the Ohio Department of Health . The sponsors had no involvement in study design; in data collection, analysis and interpretation; in writing of the manuscript; and in the decision to submit the article for publication. Publisher Copyright: © 2021 Elsevier Inc.
PY - 2021/6
Y1 - 2021/6
N2 - Objective: We investigated the effects of chronic exposures to particulate and traffic-related air pollution on allostatic load (AL) score, a marker of cumulative biological risk, among youth with type 1 diabetes. Research design and methods: Participants were drawn from five clinical sites of the SEARCH for Diabetes in Youth (SEARCH) study (n = 2338). Baseline questionnaires, anthropometric measures, and a fasting blood test were taken at a clinic visit between 2001 and 2005. AL was operationalized using 10 biomarkers reflecting cardiovascular, metabolic, and inflammatory risk. Annual residential exposures to PM2.5 and proximity to heavily-trafficked major roadways were estimated for each participant. Poisson regression models adjusted for sociodemographic and lifestyle factors were conducted for each exposure. Results: No significant associations were observed between exposures to PM2.5 or proximity to traffic and AL score, however analyses were suggestive of effect modification by race for residential distance to heavily-trafficked major roadways (p = 0.02). In stratified analyses, residing <100, 100-<200 and 200-<400 m compared to 400 m or more from heavily-trafficked major roadways was associated with 11%, 26% and 14% increases in AL score, respectively (95% CIs: -4, 29; 9, 45; −1, 30) for non-white participants compared to 6%, −2%, and −2% changes (95% CIs: -2, 15; −10, 7; −8, 6) for white participants. Conclusions: Among this population of youth with type 1 diabetes, we did not observe consistent relationships between chronic exposures to particulate and traffic-related air pollution and changes in AL score, however associations for traffic-related pollution exposures may differ by race/ethnicity and warrant further examination.
AB - Objective: We investigated the effects of chronic exposures to particulate and traffic-related air pollution on allostatic load (AL) score, a marker of cumulative biological risk, among youth with type 1 diabetes. Research design and methods: Participants were drawn from five clinical sites of the SEARCH for Diabetes in Youth (SEARCH) study (n = 2338). Baseline questionnaires, anthropometric measures, and a fasting blood test were taken at a clinic visit between 2001 and 2005. AL was operationalized using 10 biomarkers reflecting cardiovascular, metabolic, and inflammatory risk. Annual residential exposures to PM2.5 and proximity to heavily-trafficked major roadways were estimated for each participant. Poisson regression models adjusted for sociodemographic and lifestyle factors were conducted for each exposure. Results: No significant associations were observed between exposures to PM2.5 or proximity to traffic and AL score, however analyses were suggestive of effect modification by race for residential distance to heavily-trafficked major roadways (p = 0.02). In stratified analyses, residing <100, 100-<200 and 200-<400 m compared to 400 m or more from heavily-trafficked major roadways was associated with 11%, 26% and 14% increases in AL score, respectively (95% CIs: -4, 29; 9, 45; −1, 30) for non-white participants compared to 6%, −2%, and −2% changes (95% CIs: -2, 15; −10, 7; −8, 6) for white participants. Conclusions: Among this population of youth with type 1 diabetes, we did not observe consistent relationships between chronic exposures to particulate and traffic-related air pollution and changes in AL score, however associations for traffic-related pollution exposures may differ by race/ethnicity and warrant further examination.
KW - Air pollution
KW - Allostatic load
KW - Chronic exposure
KW - Type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85104144135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85104144135&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2021.111075
DO - 10.1016/j.envres.2021.111075
M3 - Article
C2 - 33798519
AN - SCOPUS:85104144135
VL - 197
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
M1 - 111075
ER -