The Relationship between Total Fibroid Burden and First Trimester Bleeding and Pain

Kara A. Michels, Katherine E. Hartmann, Kristin R. Archer, Fei Ye, Digna R. Velez Edwards

Research output: Contribution to journalArticle

Abstract

Background Few studies comment on the association between fibroids and symptoms among pregnant women. These studies generally are retrospective and do not to assess the influence of number of tumours or their volume on risk of symptoms. Methods Right from the Start is a prospective cohort that enrolled pregnant women from the southeastern USA between 2000 and 2012. In the first trimester, all participants had standardised ultrasounds to determine the presence or absence of fibroids. Symptoms were queried in a telephone survey. We used polytomous logistic regression to model odds of bleeding, pain, or both symptoms in relation to increasing total fibroid number and volume among white and black women. Results Among 4509 participants, the prevalence of fibroids was 11%. Among those reporting symptoms (70%), 11% reported only bleeding, 59% reported only pain, and 30% reported both symptoms. After adjusting for age, race, parity, hypertension, smoking, alcohol use, and study site, increasing number of fibroids was associated with pain [odds ratio (OR) 1.16, 95% confidence interval (CI) 1.00, 1.33] and both symptoms [OR 1.25, 95% CI 1.08, 1.45] but not with bleeding among all women. Fibroid volume was not associated with symptoms among black women, but white women with the smallest fibroid volumes were more likely to report both symptoms than those without fibroids [OR 1.79, 95% CI 1.17, 2.72]. Conclusions Very large tumours are not requisite for experiencing symptoms, as small fibroids and increasing number of tumours are associated with pain and both symptoms.

Original languageEnglish (US)
Pages (from-to)115-123
Number of pages9
JournalPaediatric and Perinatal Epidemiology
Volume30
Issue number2
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Fingerprint

Leiomyoma
First Pregnancy Trimester
Hemorrhage
Pain
Odds Ratio
Confidence Intervals
Pregnant Women
Parity
Telephone
Neoplasms
Retrospective Studies
Logistic Models
Smoking
Alcohols
Hypertension

Keywords

  • leiomyoma
  • pain
  • pregnancy
  • prospective studies
  • uterine haemorrhage

ASJC Scopus subject areas

  • Epidemiology
  • Pediatrics, Perinatology, and Child Health

Cite this

Michels, K. A., Hartmann, K. E., Archer, K. R., Ye, F., & Velez Edwards, D. R. (2016). The Relationship between Total Fibroid Burden and First Trimester Bleeding and Pain. Paediatric and Perinatal Epidemiology, 30(2), 115-123. https://doi.org/10.1111/ppe.12256

The Relationship between Total Fibroid Burden and First Trimester Bleeding and Pain. / Michels, Kara A.; Hartmann, Katherine E.; Archer, Kristin R.; Ye, Fei; Velez Edwards, Digna R.

In: Paediatric and Perinatal Epidemiology, Vol. 30, No. 2, 01.03.2016, p. 115-123.

Research output: Contribution to journalArticle

Michels, KA, Hartmann, KE, Archer, KR, Ye, F & Velez Edwards, DR 2016, 'The Relationship between Total Fibroid Burden and First Trimester Bleeding and Pain', Paediatric and Perinatal Epidemiology, vol. 30, no. 2, pp. 115-123. https://doi.org/10.1111/ppe.12256
Michels, Kara A. ; Hartmann, Katherine E. ; Archer, Kristin R. ; Ye, Fei ; Velez Edwards, Digna R. / The Relationship between Total Fibroid Burden and First Trimester Bleeding and Pain. In: Paediatric and Perinatal Epidemiology. 2016 ; Vol. 30, No. 2. pp. 115-123.
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