TY - JOUR
T1 - The relationship between the metabolic syndrome and arterial wall thickness
T2 - A mosaic still to be interpreted
AU - Scuteri, Angelo
AU - Franco, Oscar H.
AU - Majiid, Al Ghatrif
AU - Jolita, Badariene
AU - Sergey, Boytsov
AU - Cheng, Hao Min
AU - Chen, Chen Huan
AU - Choi, Seong Woo
AU - Francesco, Cucca
AU - De Buyzere, Marc L.
AU - Delitala, Alessandro
AU - Marcus, Dorr
AU - Gunnar, Engstrom
AU - Albert, Hofman
AU - Seul-Ki, Jeong
AU - Kweon, Sun Seog
AU - Michel, Langlois
AU - Lee, Young Hoon
AU - Mattace Raso, Francesco
AU - Olle, Melander
AU - Morrell, Cristopher H.
AU - Park, Kyeong Soo
AU - Rietzschel, Ernst R.
AU - Kristina, Ryliskiene
AU - Ryliskyte, Ligita
AU - Ulf, Schminke
AU - David, Schlessinger
AU - Shin, Min Ho
AU - Irina, Strazhesko
AU - Shih-Hsien, Sung
AU - Olga, Tkacheva
AU - Volzke, Henry
AU - Lakatta, Edward G.
AU - Nilsson, Peter
N1 - Funding Information:
SHIP is part of the Community Medicine Network of the University Medicine Greifswald. The network was initially funded by the Federal Ministry of Education and Research as well as the Federal State of Mecklenburg-West Pomerania.
Funding Information:
The Malmoe Diet Cancer – Cardiovascular Study was supported by grants from the Swedish Research Council ( K2008-65X-20752-01-3 , K2011-65X-20752-04-6 ), the Lundströms Foundation, the Swedish Heart-Lung Foundation ( 2010-0244; 2013-0249 ) and ALF government grants (Dnr: 2012/1789 ).
Funding Information:
The Asklepios Study is supported by the Fund for Scientific Research – Flanders (FWO research grants G042703 and G083810N ).
Funding Information:
The Dong-gu Study and the Namwon Study were supported by Research Institute of Medical Sciences, Chonnam National University .
Funding Information:
The Rotterdam Study is supported by the Erasmus Medical Center and Erasmus University Rotterdam ; the Netherlands Organization for Scientific Research ; the Netherlands Organization for Health Research and Development (ZonMw) ; the Research Institute for Diseases in the Elderly (RIDE) ; the Netherlands Heart Foundation; the Ministry of Education, Culture and Science ; the Ministry of Health Welfare and Sports; the European Commission ; and the Municipality of Rotterdam .
Funding Information:
The Kingmen Aging study was supported, in part, by a grant from the National Science Council ( NSC 99-2314-B-010-034-MY3 ), an intramural grant from the Taipei Veterans General Hospital (grant V102C-119 ), Research and Development contract NO1-AG-1-2118, and the Intramural Research Program of the National Institute on Aging, National Institutes of Health .
Funding Information:
The SardiNIA team was supported by Contract NO1-AG-1-2109 from the NIA . This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging (USA).
Publisher Copyright:
© 2016 Elsevier Ireland Ltd
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Background and aims We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness. Methods We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium. Results Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal obesity (TBW), low HDL cholesterol-high blood pressure-abdominal obesity (HBW), high glucose-high blood pressure-abdominal obesity (GBW) - were accompanied by a 50–90% significantly greater likelihood of presenting extremely high intima-media thickness (via ultrasound of carotid artery, CCA IMT), after controlling for age, sex, smoking, non-HDL cholesterol, and presence of diabetes mellitus. This likelihood is comparable to the effect of being 7–8 years older or of being a cigarette smoker or of having non-HDL cholesterol 50 mg/dl higher. Conclusions The consistent association of specific clusters of MetS components with extremely thick (older) large artery cross-culturally suggests that identification of those clusters in clinical practice will facilitate a personalized health care and a better – i.e. more healthy and cost-effective - prevention of major cardiovascular (CV) events.
AB - Background and aims We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness. Methods We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium. Results Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal obesity (TBW), low HDL cholesterol-high blood pressure-abdominal obesity (HBW), high glucose-high blood pressure-abdominal obesity (GBW) - were accompanied by a 50–90% significantly greater likelihood of presenting extremely high intima-media thickness (via ultrasound of carotid artery, CCA IMT), after controlling for age, sex, smoking, non-HDL cholesterol, and presence of diabetes mellitus. This likelihood is comparable to the effect of being 7–8 years older or of being a cigarette smoker or of having non-HDL cholesterol 50 mg/dl higher. Conclusions The consistent association of specific clusters of MetS components with extremely thick (older) large artery cross-culturally suggests that identification of those clusters in clinical practice will facilitate a personalized health care and a better – i.e. more healthy and cost-effective - prevention of major cardiovascular (CV) events.
KW - Arterial ageing
KW - Arteries
KW - Carotid intima-media thickness
KW - Metabolic syndrome
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U2 - 10.1016/j.atherosclerosis.2016.10.032
DO - 10.1016/j.atherosclerosis.2016.10.032
M3 - Article
C2 - 27794213
AN - SCOPUS:84994017997
SN - 0021-9150
VL - 255
SP - 11
EP - 16
JO - Atherosclerosis
JF - Atherosclerosis
ER -