TY - JOUR
T1 - The relationship between race and HIV-distal sensory polyneuropathy in a large cohort of US women
AU - Anziska, Yaacov
AU - Helzner, Elizabeth P.
AU - Crystal, Howard
AU - Glesby, Marshall J.
AU - Plankey, Michael
AU - Weber, Kathleen
AU - Golub, Elizabeth
AU - Burian, Pamela
N1 - Funding Information:
The WIHS is funded by the National Institute of Allergy and Infectious Diseases ( UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590 ) and by the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( UO1-HD-32632 ). The study is co-funded by the National Cancer Institute , the National Institute on Drug Abuse , and the National Institute on Deafness and Other Communication Disorders . Funding is also provided by the National Center for Research Resources (UCSF-CTSI grant number UL1 RR024131 ). This study was also supported by NIAID K24 A178884 .
PY - 2012/4/15
Y1 - 2012/4/15
N2 - Introduction: HIV-distal sensory polyneuropathy (HIV-DSPN) is a common complication of HIV infection, yet race as a potential risk factor is not known. Methods: Between April and October 2009, as part of the NIH Women's Interagency HIV Study (WIHS), 1414 women, 973 of whom were HIV-infected, were clinically evaluated for peripheral neuropathy. Utilizing available clinical, laboratory, and sociodemographic variables, we conducted a cross-sectional analysis of factors associated with HIV-DSPN. Multivariable logistic regression was used to examine factors independently associated with HIV-DSPN. Results: 36% of HIV-infected women met our definition of HIV-DSPN. 41.3% of African Americans, 34.8% of Whites and 24.7% of Hispanics had DSPN. Age, Hepatitis C-co-infection, and diabetes were each significantly associated with HIV-DSPN. After controlling for age, diabetes, Hepatitis C co-infection, alcohol use, current dideoxy-nucleoside reverse transcriptase inhibitor use, current CD4 count, and plasma HIV viral load, HIV-DSPN was significantly associated with ethnicity; the odds ratio was 1.67 (p = 0.001) in African-Americans compared to other racial groups. Conclusion: The prevalence of HIV-DSPN in women was lower than reported in prior studies. The likelihood of HIV-DSPN was higher in African-Americans compared to other racial groups. HIV-DSPN was more common in those co-infected with Hepatitis C, older individuals, and diabetics. Further prospective studies are needed to explore the relationship between gender, race, and HIV-DSPN, and the mechanistic basis for racial differences.
AB - Introduction: HIV-distal sensory polyneuropathy (HIV-DSPN) is a common complication of HIV infection, yet race as a potential risk factor is not known. Methods: Between April and October 2009, as part of the NIH Women's Interagency HIV Study (WIHS), 1414 women, 973 of whom were HIV-infected, were clinically evaluated for peripheral neuropathy. Utilizing available clinical, laboratory, and sociodemographic variables, we conducted a cross-sectional analysis of factors associated with HIV-DSPN. Multivariable logistic regression was used to examine factors independently associated with HIV-DSPN. Results: 36% of HIV-infected women met our definition of HIV-DSPN. 41.3% of African Americans, 34.8% of Whites and 24.7% of Hispanics had DSPN. Age, Hepatitis C-co-infection, and diabetes were each significantly associated with HIV-DSPN. After controlling for age, diabetes, Hepatitis C co-infection, alcohol use, current dideoxy-nucleoside reverse transcriptase inhibitor use, current CD4 count, and plasma HIV viral load, HIV-DSPN was significantly associated with ethnicity; the odds ratio was 1.67 (p = 0.001) in African-Americans compared to other racial groups. Conclusion: The prevalence of HIV-DSPN in women was lower than reported in prior studies. The likelihood of HIV-DSPN was higher in African-Americans compared to other racial groups. HIV-DSPN was more common in those co-infected with Hepatitis C, older individuals, and diabetics. Further prospective studies are needed to explore the relationship between gender, race, and HIV-DSPN, and the mechanistic basis for racial differences.
KW - African-Americans
KW - Diabetes
KW - Gender
KW - HIV-associated sensory polyneuropathy
KW - Hepatitis C
KW - Race
KW - Women
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U2 - 10.1016/j.jns.2011.11.009
DO - 10.1016/j.jns.2011.11.009
M3 - Article
C2 - 22123155
AN - SCOPUS:84857995553
SN - 0022-510X
VL - 315
SP - 129
EP - 132
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -