The relationship between neurally mediated hypotension and the chronic fatigue syndrome

I. Bou-Holaigah, Peter Rowe, J. Kan, Hugh Calkins

Research output: Contribution to journalArticle

Abstract

Objective. - To compare the clinical symptoms and response evoked by upright tilt-table testing in healthy individuals and in a sample of those satisfying strict criteria for chronic fatigue syndrome. Design. - Case- comparison study with mean (SD) follow-up of 24 (5) weeks. Setting. - Tertiary care hospital. Patients and Other Participants. - A sample of 23 patients with chronic fatigue syndrome (five men and 18 women; mean age, 34 years), each of whom fulfilled the strict diagnostic criteria of the Centers for Disease Control and Prevention, was recruited from regional chronic fatigue support groups and from the investigators' clinical practices. There were 14 healthy controls (four men and 10 women; mean age, 36 years). Interventions. - Each subject completed a symptom questionnaire and underwent a three-stage upright tilt-table test (stage 1,45 minutes at 70° tilt; stage 2, 15 minutes at 70° tilt with 1 to 2 μg/min of isoproterenol; and stage 3, 10 minutes at 70° with 3 to 4 μg/min of isoproterenol). Patients were offered therapy with fludrocortisone, β-adrenergic blocking agents, and disopyramide, alone or in combination, directed at neurally mediated hypotension. Main Outcome Measures. - Response to upright tilt and scores on symptom questionnaires prior to and during follow-up. Results. - An abnormal response to upright tilt was observed in 22 of 23 patients with chronic fatigue syndrome vs four of 14 controls (P

Original languageEnglish (US)
Pages (from-to)961-967
Number of pages7
JournalJournal of the American Medical Association
Volume274
Issue number12
StatePublished - 1995

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Chronic Fatigue Syndrome
Hypotension
Isoproterenol
Tilt-Table Test
Fludrocortisone
Disopyramide
Adrenergic Antagonists
Self-Help Groups
Tertiary Healthcare
Centers for Disease Control and Prevention (U.S.)
Tertiary Care Centers
Fatigue
Case-Control Studies
Research Personnel
Outcome Assessment (Health Care)
Surveys and Questionnaires
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The relationship between neurally mediated hypotension and the chronic fatigue syndrome. / Bou-Holaigah, I.; Rowe, Peter; Kan, J.; Calkins, Hugh.

In: Journal of the American Medical Association, Vol. 274, No. 12, 1995, p. 961-967.

Research output: Contribution to journalArticle

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