TY - JOUR
T1 - The relationship between migraine and lipid sub-fractions among individuals without cardiovascular disease
T2 - A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
AU - Goulart, Alessandra C.
AU - Lotufo, Paulo A.
AU - Santos, Itamar S.
AU - Bittencourt, Márcio S.
AU - Santos, Raul D.
AU - Blaha, Michael J.
AU - Jones, Steven
AU - Toth, Peter P.
AU - Kulkarni, Krishnaji
AU - Benseñor, Isabela M.
N1 - Publisher Copyright:
© 2017, © International Headache Society 2017.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Introduction: Recent studies have explored the relationship between dyslipidemia and migraine in a cardiovascular context. Thus, we aimed to evaluate the possible association between lipids, lipoprotein subfractions and migraine according to aura symptoms in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: 1,560 women and 1,595 men, without CVD or lipid disorders requiring medication, underwent a baseline clinical assessment. Total-cholesterol and its sub-fractions (LDL, VLDL and HDL subclass cholesterol); triglycerides and triglyceride-rich lipoprotein cholesterol [TRL-C (VLDL1+2-C VLDL3-C + IDL-C)] were determined by vertical auto profile (VAP). We also calculated logarithmic LDL density ratio [LLDR = ln ((LDL3-C + LDL4-C)/(LDL1-C + LDL2-C))], T-Chol/HDL-C and triglycerides/HDL-C ratios. Odds ratios (OR) with 95% confidence intervals (CI) were obtained to evaluate the relationship between lipids tertiles and migraine for both sexes. Results: Main findings revealed positive associations between migraine without aura (MO) and the highest tertiles of VLDL-C (OR, 1.61; 95%CI, 1.07–2.40) and TRL-C (OR, 1.55; 95% CI, 1.03–2.34) in women. In men, the highest tertile of VLDL3-C (OR, 3.87; 95%CI, 1.23–12.19) was positively associated with MO, as well. Conclusions: In middle-aged participants without CVD or lipid disorders requiring medication, the worst lipid profile was determined by the highest levels of TRL-C and their cholesterol-rich remnants in migraineurs without aura for both sexes.
AB - Introduction: Recent studies have explored the relationship between dyslipidemia and migraine in a cardiovascular context. Thus, we aimed to evaluate the possible association between lipids, lipoprotein subfractions and migraine according to aura symptoms in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: 1,560 women and 1,595 men, without CVD or lipid disorders requiring medication, underwent a baseline clinical assessment. Total-cholesterol and its sub-fractions (LDL, VLDL and HDL subclass cholesterol); triglycerides and triglyceride-rich lipoprotein cholesterol [TRL-C (VLDL1+2-C VLDL3-C + IDL-C)] were determined by vertical auto profile (VAP). We also calculated logarithmic LDL density ratio [LLDR = ln ((LDL3-C + LDL4-C)/(LDL1-C + LDL2-C))], T-Chol/HDL-C and triglycerides/HDL-C ratios. Odds ratios (OR) with 95% confidence intervals (CI) were obtained to evaluate the relationship between lipids tertiles and migraine for both sexes. Results: Main findings revealed positive associations between migraine without aura (MO) and the highest tertiles of VLDL-C (OR, 1.61; 95%CI, 1.07–2.40) and TRL-C (OR, 1.55; 95% CI, 1.03–2.34) in women. In men, the highest tertile of VLDL3-C (OR, 3.87; 95%CI, 1.23–12.19) was positively associated with MO, as well. Conclusions: In middle-aged participants without CVD or lipid disorders requiring medication, the worst lipid profile was determined by the highest levels of TRL-C and their cholesterol-rich remnants in migraineurs without aura for both sexes.
KW - Migraine with aura
KW - lipids
KW - lipoproteins
KW - observational study
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U2 - 10.1177/0333102417699181
DO - 10.1177/0333102417699181
M3 - Article
C2 - 28486852
AN - SCOPUS:85044380487
SN - 0333-1024
VL - 38
SP - 528
EP - 542
JO - Cephalalgia
JF - Cephalalgia
IS - 3
ER -