TY - JOUR
T1 - The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema
AU - Hatef, Elham
AU - Colantuoni, Elizabeth
AU - Wang, Jianmin
AU - Ibrahim, Mohamed
AU - Shulman, Matthew
AU - Adhi, Fatima
AU - Sepah, Yasir Jamal
AU - Channa, Roomasa
AU - Khwaja, Afsheen
AU - Nguyen, Quan Dong
AU - Do, Diana V.
N1 - Funding Information:
The scanning laser ophthalmoscope/spectral domain optical coherence tomography (SLO/OCTTM) was provided by OPKO Health, Inc, Toronto, Canada. Publication of this article was supported in part through the Physician Scientist Award from the Research to Prevent Blindness, New York, New York (Q.D.N.) as well as the Macular Research Fund (E.H.). The authors indicate no financial disclosures. Involved in design and conduct of the study (Q.D.N., D.V.D., E.H., J.W., M.I.); collection (Q.D.N., D.V.D., E.H., J.W., M.I.), management (Q.D.N., D.V.D.), analysis (E.H., E.C.), and interpretation of the data (Q.D.N., D.V.D., E.H., E.C.); and preparation, review, or approval of the manuscript (Q.D.N., D.V.D., E.H., M.S., F.A., Y.J.S., R.C., A.K.). The study and data accumulation were carried out with approval from the Johns Hopkins Institutional Review Board (IRB), and informed consent for the research was obtained from the patients or subjects. This study is in accordance with HIPAA regulations.
PY - 2011/9
Y1 - 2011/9
N2 - Purpose: To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME). Design: Prospective observational study. Methods: settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness. Results: Fixation stability revealed that 21 eyes (95.4%) had stable fixation (>75% within central 2 degrees of point of fixation) and 1 eye (4.5%) had relatively unstable fixation (<75% of fixation points located within 2 degrees, >75% located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2%) had central (>50% of fixation points within 0.5 mm of fovea), 3 eyes (13.6%) pericentral (25% to 50% within 0.5 mm of fovea), and 4 eyes (18.2%) eccentric (<25% of fixation points within 0.5 mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03 decibel (dB) (95% confidence interval [CI]: 0.00, 0.06) per 1-micron (μm) increase in retinal thickness for thickness values ≤280 μm measured with the OPKO/OTI spectral-domain OCT. The macular sensitivity decreased by an average 0.05 dB (95% CI: -0.08, -0.02) per 1-μm increase in thickness for thickness values >280 μm. Conclusions: In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.
AB - Purpose: To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME). Design: Prospective observational study. Methods: settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness. Results: Fixation stability revealed that 21 eyes (95.4%) had stable fixation (>75% within central 2 degrees of point of fixation) and 1 eye (4.5%) had relatively unstable fixation (<75% of fixation points located within 2 degrees, >75% located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2%) had central (>50% of fixation points within 0.5 mm of fovea), 3 eyes (13.6%) pericentral (25% to 50% within 0.5 mm of fovea), and 4 eyes (18.2%) eccentric (<25% of fixation points within 0.5 mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03 decibel (dB) (95% confidence interval [CI]: 0.00, 0.06) per 1-micron (μm) increase in retinal thickness for thickness values ≤280 μm measured with the OPKO/OTI spectral-domain OCT. The macular sensitivity decreased by an average 0.05 dB (95% CI: -0.08, -0.02) per 1-μm increase in thickness for thickness values >280 μm. Conclusions: In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.
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U2 - 10.1016/j.ajo.2011.02.024
DO - 10.1016/j.ajo.2011.02.024
M3 - Article
C2 - 21696702
AN - SCOPUS:80051877718
SN - 0002-9394
VL - 152
SP - 400-405.e2
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 3
ER -